Evaluation of propylene oxide for mutagenic activity in 3 in vivo test systems

1983 ◽  
Vol 117 (3-4) ◽  
pp. 337-344 ◽  
Author(s):  
Bryan D. Hardin ◽  
Ronald L. Schuler ◽  
Patricia M. McGinnis ◽  
Richard W. Niemeier ◽  
Randall J. Smith
Keyword(s):  
Propylene Oxide ◽  
Mutagenic Activity ◽  
In Vivo Test ◽  
Test Systems

scholarly journals Acute Toxicity of Grape, Plum and Orange Synthetic Food Flavourings Evaluated in in vivo Test Systems

2017 ◽  
Vol 55 (1) ◽  
Author(s):  
Ila Monize Souza Sales ◽  
◽  
Janaína Sousa Barbosa ◽  
Fabelina Karolyne Sousa dos Santos ◽  
Felipe Cavalcanti Carneiro da Silva ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
In Vivo Test ◽  
Test Systems

Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems

2003 ◽  
Vol 466 (1-2) ◽  
pp. 137-146 ◽  
Author(s):  
Atsushi Sugiyama ◽  
Yoshioki Satoh ◽  
Akira Takahara ◽  
Yuji Nakamura ◽  
Masao Shimizu-Sasamata ◽  
...  
Keyword(s):  
Experimental Evidence ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
In Vivo Test ◽  
Test Systems ◽  
Qt Syndrome

Cycloheximide genotoxicity in in vitro and in vivo test systems

1991 ◽  
Vol 263 (4) ◽  
pp. 203-210 ◽  
Author(s):  
Tamara Bašić-Zaninović ◽  
Dražena Papeš ◽  
Jasna Franekić
Keyword(s):  
In Vivo Test ◽  
Test Systems

scholarly journals Use of Grape Polyphenols Against Carcinogenesis: Putative Molecular Mechanisms of Action Using In Vitro and In Vivo Test Systems

2013 ◽  
Vol 16 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Andrea P.B. Gollucke ◽  
Odair Aguiar ◽  
Luis Fernando Barbisan ◽  
Daniel Araki Ribeiro
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Grape Polyphenols ◽  
In Vivo Test ◽  
Test Systems

Assay of phenacetin genotoxicity using in vitro and in vivo test systems

1985 ◽  
Vol 16 (3-4) ◽  
pp. 355-377 ◽  
Author(s):  
Silvio De Flora ◽  
Patrizia Russo ◽  
Mauro Pala ◽  
Gianfranco Fassina ◽  
Annalisa Zunino ◽  
...  
Keyword(s):  
In Vivo Test ◽  
Test Systems

Defibrotide Inhibits Platelet Activation by Cathepsin G Released From Stimulated Polymorphonuclear Leukocytes

1992 ◽  
Vol 67 (06) ◽  
pp. 660-664 ◽  
Author(s):  
Virgilio Evangelista ◽  
Paola Piccardoni ◽  
Giovanni de Gaetano ◽  
Chiara Cerletti
Keyword(s):  
Platelet Activation ◽  
Polymorphonuclear Leukocytes ◽  
Direct Interaction ◽  
Cathepsin G ◽  
In Vivo Test ◽  
Cell Functions ◽  
Test Models ◽  
Antithrombotic Effects

SummaryDefibrotide is a polydeoxyribonucleotide with antithrombotic effects in experimental animal models. Most of the actions of this drug have been observed in in vivo test models but no effects have been reported in in vitro systems. In this paper we demonstrate that defibrotide interferes with polymorphonuclear leukocyte-induced human platelet activation in vitro. This effect was not related to any direct interaction with polymorphonuclear leukocytes or platelets, but was due to the inhibition of cathepsin G, the main biochemical mediator of this cell-cell cooperation. Since cathepsin G not only induces platelet activation but also affects some endothelial cell functions, the anticathepsin G activity of defibrotide could help to explain the antithrombotic effect of this drug.

Comparative Evaluation of In Vitro and In Vivo Assays for the Detection of Avian Infectious Bronchitis Virus as a Contaminant of Live Poultry Vaccines

1998 ◽  
Vol 26 (5) ◽  
pp. 629-634
Author(s):  
Emiliana Falcone ◽  
Edoardo Vignolo ◽  
Livia Di Trani ◽  
Simona Puzelli ◽  
Maria Tollis
Keyword(s):  
Infectious Bronchitis Virus ◽  
Serological Response ◽  
Avian Infectious Bronchitis Virus ◽  
Animal Testing ◽  
Rt Pcr ◽  
Pcr Assay ◽  
In Vivo Test ◽  
Infectious Bronchitis

A reverse transcriptase polymerase chain reaction (RT-PCR) assay specific for identifying avian infectious bronchitis virus (IBV) in poultry vaccines, and the serological response to IBV induced by the inoculation of chicks with a Newcastle disease vaccine spiked with the Massachusetts strain of IBV, were compared for their ability to detect IBV as a contaminant of avian vaccines. The sensitivity of the IBV-RT-PCR assay provided results which were at least equivalent to the biological effect produced by the inoculation of chicks, allowing this assay to be considered a valid alternative to animal testing in the quality control of avian immunologicals. This procedure can easily be adapted to detect a number of contaminants for which the in vivo test still represents the only available method of detection.

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