Rubiadin exerts an acute and chronic anti-inflammatory effect in rodents

Rubiadin is identified as a bioactive anthraquinone that exists in some quinone rich plants. The current research was carried out to evaluate the potential anti-inflammatory impact of Rubiadin in acute and chronic inflammation test models in rodents. The anti-inflammatory activity of Rubiadin was examined in cotton pellet-induced granuloma and carrageenan-induced edema as chronic and acute inflammation models in rats. TNF-α level and histopathological changes were assessed using sampled foot tissue of rat in the acute model. Also, the IL-1β level was assessed in the chronic model. One-way ANOVA (post hoc Tukey’s) analysis was used for comparing the groups. Rubiadin (0.5 mg/kg, i.p.) induced a significant reduction in TNF α level and the paw edema compared to the control group in carrageenan test. Also, it was observed that the anti-inflammatory activity of Rubiadin (0.5 mg/kg, i.p.) is comparable to mefenamic acid (30 mg/kg, i.p.) as the standard drug. Rubiadin was effective in granuloma induced by cotton pellet concerning the granuloma and transudate formation amount. Rubiadin’s anti-inflammatory effects were associated with a significant IL-1β decrease in this model. The results suggest that Rubiadin as a natural compound can possess significant peripheral anti-inflammatory impacts.

Media Generation and Pharmacy Regulatory Authority Awareness

Background: Professional regulatory authorities play a critical role in protecting public interest. Yet, there is a growing view that trust in regulatory authorities may be on the decline. Objective: Awareness has been identified as important for maintaining trust. However, research that examines public awareness and trust in pharmacy regulatory authorities (PRAs) is lacking. This research explores public awareness and trust of PRAs and presents recommendations to enhance PRA communication strategies. Methods: An online survey was conducted with the Nova Scotia (Canada) public in 2020. Adopting classifications from the Communications literature, 3 media generations were explored: newspaper, television, and the Internet. The χ2 test of independence and Kruskal-Wallis H test were adopted to explore differences between the generations. Results: Six hundred sixty-two usable surveys were obtained. Over 80% of those surveyed were aware of the existence of the PRA. Those who had heard of the PRA were most aware of its operational responsibilities and less aware of its governance. The Internet Generation was more aware that the PRA includes members of the public in its decision making than expected and showed increased trust toward the PRA versus the other media generations. Conclusion: The findings should help inform PRA communication plans and set baselines to assess whether such plans enhance awareness. Future studies should explore additional aspects of PRA awareness and trust, perform comparisons across pharmacy jurisdictions, and develop and test models of the relationship between PRA awareness and various dimensions of institutional trust.

Testing Models of Data-Driven Reporting in Newspapers for Health Communication

In the second wave of the novel corona virus pandemic, where misinformation and infodemic are at their peak, data-driven reporting acts as a solution to curb misinformation and infodemic worldwide. Therefore, it is important to analyse the newspaper coverage of the COVID-19 second wave by using models of data-driven reporting in newspapers based on purpose, relationship, data presentation, type, and structure. The objective of this research was to analyse the data-driven reporting of COVID-19 and test models of data-driven reporting in the field of health communication. This research study was based on a quantitative approach, using content analysis research method, and the tool of data collection was secondary. The unstructured sampling technique was taken into consideration which included two English national dailies of India for five consecutive days. Results of this study helped the researcher in analysing data-driven reporting of COVID-19 second wave and testifying these models in the field of health communication.

PENGARUH PELATIHAN DAN KOMPETENSI INSTRUKTUR TERHADAP KINERJA PEGAWAI BALAI LATIHAN KERJA KABUPATEN PANGKEP

Penelitian ini untuk mengetahui hubungan antara pengaruh pelatihan dan kompetensi instruktur terhadap kinerja pegawai balai latihan kerja kabupaten pangkep. Analisis yang digunakan adalah analisis regresi linear berganda dengan model uji t dan uji F. Dari hasil pengujian regresi linear berganda diketahui bahwa pelatihan dan kompetensi berpengaruh positif dan signifikan terhadap kinerja pegawai. Indikator Kebutuhan pelatihan, Sasaran pelatihan, Kurikulum pelatihan, Peserta pelatihan, dan Pelatih (trainer), mempengaruhi kinerja pegawai telah menjadi bukti empirik sebagai syarat peningkatkan kinerja pegawai.. Pengeloaan data regresi berganda yang dilakukan dalam penelitian ini memberikan hasil bahwa pelatihan, kompetensi instruktur berpengaruh positif dan signifikan terhadap kinerja pegawai pada Balai Latihan Krja Kabupaten Pangkep. Hal ini dapat dilihat dari nilai probabilitas yang lebih kecil dari nilai standar. Nilai F hitung yang lebih besar dari nilai F tabel menjadi tolak ukur hasil dari penelitian ini tentang pengaruh setiap variable. This study was to determine the relationship between training and competence on the performance of the Pangkep district job training center employees. The analysis used is multiple linear regression analysis with t test and F test models. It is known from the results of multiple linear regression testing that training and competence have a positive and significant effect on employee performance. Indicators of training needs, training targets, training curriculum, training, and trainers, affect employee performance as a condition for improving employee performance. positive and significant impact on employee performance at the Pangkep Regency Job Training Center. This can be seen from the probability value which is smaller than the standard. The calculated F value which is greater than the F table value becomes the benchmark for the results of this study regarding the effect of each variable

Investigating errors when forecasting processes with uncertain dynamics and observation noise by the self-adjusting brown's zero-order model

This paper reports a study into the errors of process forecasting under the conditions of uncertainty in the dynamics and observation noise using a self-adjusting Brown's zero-order model. The dynamics test models have been built for predicted processes and observation noises, which make it possible to investigate forecasting errors for the self-adjusting and adaptive models. The test process dynamics were determined in the form of a rectangular video pulse with a fixed unit amplitude, a radio pulse of the harmonic process with an amplitude attenuated exponentially, as well as a video pulse with amplitude increasing exponentially. As a model of observation noise, an additive discrete Gaussian process with zero mean and variable value of the mean square deviation was considered. It was established that for small values of the mean square deviation of observation noise, a self-adjusting model under the conditions of dynamics uncertainty produces a smaller error in the process forecast. For the test jump-like dynamics of the process, the variance of the forecast error was less than 1 %. At the same time, for the adaptive model, with an adaptation parameter from the classical and beyond-the-limit sets, the variance of the error was about 20 % and 5 %, respectively. With significant observation noises, the variance of the error in the forecast of the test process dynamics for the self-adjusting and adaptive models with a parameter from the classical set was in the range from 1 % to 20 %. However, for the adaptive model, with a parameter from the beyond-the-limit set, the variance of the prediction error was close to 100 % for all test models. It was established that with an increase in the mean square deviation of observation noise, there is greater masking of the predicted test process dynamics, leading to an increase in the variance of the forecast error when using a self-adjusting model. This is the price for predicting processes with uncertain dynamics and observation noises.

Testing as an Effective Method for Assessing the Quality of Students' Training Achievements

Electronic educational resources including testing, which simplify the process of searching and structuring educational information have been used more often in educational organizations recently. They have made learning more accessible and interesting for students of higher and vocational education institutions, especially in the context of a pandemic. The article provides a brief theoretical justification of the advantages of testing students' academic achievements. The emphasis is placed on the importance of testing as a tool for remote control of students' knowledge, the advantages and disadvantages of using tests both in the educational process of higher and secondary vocational education and in order to control the acquired knowledge are revealed. The study was carried out by the authors on the basis of a comprehensive use of theoretical and empirical methods. The leading theoretical methods were: analysis, generalization, concretization, forecasting, modeling. The work used such empirical methods as conversations, pedagogical observation, questionnaires, expert evaluation, testing, analysis of performance, generalization of pedagogical experience, methods of statistical processing of experimental data. The results presented in the article of the study of testing of students of MPSU at the initial (entrance test), current and final stage of measuring the level of educational achievements of students demonstrated an increase in the values of the effectiveness of testing at all stages of its implementation, an increase in the effectiveness of test control at the intermediate and final stages of the study. The results of the study made it possible to formulate promising directions for the development of problems of testing the quality of education of students of higher and professional education organizations: improving the forms and methods of analysis and interpretation of test results based on the invariant application of test models: improving the psychological and pedagogical orientation of the use of the testing algorithm for personalized learning trajectories in the practice of mass education, etc.

Single core configurations of saturated core fault current limiter performance of laboratory test models

Economic growth with industrialization and urbanization lead to an extensive increase in power demand. It forced the utilities to add power generating facilities to cause the necessary demand-generation balance. The bulk power generating stations, mostly interconnected, with the penetration of distributed generation result in an enormous rise in the fault level of power networks. It necessitates for electrical utilities to control the fault current so that the existing switchgear can continue its services without up-gradation or replacement for reliable supply. The deployment of fault current limiter (FCL) at the distribution and transmission networks has been under investigation as a potential solution to the problem. A saturated core fault current limiter (SCFCL) technology is a smart, scalable, efficient, reliable, and commercially viable option to manage fault levels in existing and future MV/HV supply systems. This paper presents the comparative performance analysis of two single-core SCFCL topologies impressed with different core saturations. It has demonstrated that the single AC winding configuration needs more bias power for affecting the same current limiting performance with an acceptable steady-state voltage drop contribution. The fault state impedance has a transient nature, and the optimum bias selection is a critical design parameter in realizing the SCFCL applications.

Green-Building-Index-Assessment-Criteria-Based Comparative Evaluation of Interlocking Blocks as an Alternative to Conventional Masonry for Residential Buildings in Malaysia

Major residential construction projects adopt clay bricks as masonry, which can contribute to high carbon emission, primarily due to their high embodied carbon. Furthermore, the adoption of conventional masonry, including clay bricks, may lead to the use of high amounts of mortar and contribute to a lot of wastage. Therefore, an alternative system that can potentially replace conventional masonry is required to reduce the wastage as well as carbon emission. Interlocking blocks, which adopt a lock and key system has the potential to replace conventional masonry as they employ locally available materials, save construction time, use less mortar and are less dependent on highly skilled masons. In view of their potential, the adoption of interlocking blocks in residential buildings were evaluated comparatively to conventional masonry, namely clay and cement sand bricks, based on the Green Building Index Assessment Criteria for Residential New Construction (GBI-RNC) tool. Overall Thermal Transfer Values of test models that employed conventional masonry and interlocking blocks were calculated. Approximately, based on the GBI-RNC tool, with an increase of 17-18 points achieved from the EE, MR and IN criteria, a Silver rating can be achieved with the adoption of interlocking blocks.

An Overview on Bonded Marine Hoses for Sustainable Fluid Transfer and (Un)Loading Operations via Floating Offshore Structures (FOS)

Due to the demand for oil production in varying water depth regions, the advantage of flexible buoyant conduits has led to an increase in bonded marine hoses for fluid transfer and (un)loading operations. The fluid transfer system for bonded marine hoses is dependent on floating offshore structures (FOS). This paper presents an overview of different systems for sustainable fluid transfer and (un)loading operations via FOS, such as Single Point Mooring (SPM) systems. SPMs are component aspects of the techno-economic design and FOS operation. This review aims to present sustainable fluid transfer technologies while addressing the subject of bonded marine hoses based on application, configuration, test models, hose selection criteria, hose-mooring configurations and operational views. This paper also includes an overview of the hose dynamics, with the loading and unloading (or discharging) techniques for sustainable fluid transfer via marine bonded hoses, based on operational challenges encountered. To dynamically present the hose performance in this review, an overview of the test methods’ guidance as specified in available industry standards was conducted. The pros and cons of marine hose application were also presented. Finally, this study presents different marine hose types and novel design configurations applied in implementing hose-mooring systems. Some concluding remarks with recommended solutions on the technology were presented in this review.