Study of the genotoxic activity of six halogenated acetonitriles, using the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test

1995 ◽  
Vol 341 (4) ◽  
pp. 289-302 ◽  
Author(s):  
F. Le Curieux ◽  
S. Giller ◽  
L. Gauthier ◽  
F. Erb ◽  
D. Marzin
Keyword(s):  
Micronucleus Test ◽  
Fluctuation Test ◽  
Sos Chromotest ◽  
Genotoxic Activity ◽  
Ames Fluctuation Test

scholarly journals Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americanaMill., c.v.Hass)

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Eduardo Padilla-Camberos ◽  
Moisés Martínez-Velázquez ◽  
José Miguel Flores-Fernández ◽  
Socorro Villanueva-Rodríguez
Keyword(s):  
Acute Toxicity ◽  
Traditional Medicine ◽  
Micronucleus Test ◽  
Pharmaceutical Medicine ◽  
Micronucleus Assay ◽  
Negative Control ◽  
Seed Extract ◽  
Persea Americana ◽  
Genotoxic Activity ◽  
Avocado Seed

The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products.Persea americanaseeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract ofPersea americanawas evaluated with respect to its genotoxic potential through micronucleus assay in rodents. The frequency of micronuclei in groups of animals treated with avocado seed extract showed no differences compared to the negative control (vehicle); therefore, it is considered that the avocado seed extract showed no genotoxic activity in the micronucleus test.

Genotoxicity of Aqueous Extract From Heated Cooking Oils and its Suppression by Lactobacilli

2009 ◽  
Vol 15 (3) ◽  
pp. 267-273 ◽  
Author(s):  
M. Isidori ◽  
A. Parrella
Keyword(s):  
Ames Test ◽  
Corn Oil ◽  
Sos Response ◽  
Smoke Point ◽  
Genotoxic Effects ◽  
Sos Chromotest ◽  
Genotoxic Activity ◽  
Cooking Oils ◽  
Mutagenic Effects ◽  
Double Heat Treatment

In the present study the mutagenic and genotoxic effects of aqueous extracts from six cooking oils (extra vergine olive, peanut, sunflower, soybean, corn, and various seeds oils) heated to the respective smoke point were investigated. The Ames test and the SOS Chromotest were carried out for this evaluation. The same oils were also tested after their re-frying, simulating domestic reuse process. Furthermore, the ability of different lactobacilli to reduce the potential genotoxic activity of the fried and re-fried oils was determined applying SOS Chromotest after co-incubation of samples with lactobacilli. The results showed that all the fried oils did not produce mutagenic effects while they induced a SOS response with the highest induction factor for the corn oil. Double heat-treatment caused an increase of the genotoxic activity until two times the first heating. The most susceptible oil to the re-frying procedure was the sunflower oil. The antigenotoxicity results were expressed as percent of genotoxicity inhibition. All the tested strains of lactobacilli exhibited antigenotoxic properties on the fried oils.

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