Blood-pressure variability is buffered by nitric oxide

We investigated the relationship between renal function, blood pressure variability (BPV), and nitric oxide (NO) in a group of African Americans with normal or mildly impaired renal function. 24-hour ambulatory blood pressure monitoring was performed, NO measured, and glomerular filtration rate (GFR) calculated in 38 African Americans. Participants were categorized as having normal (GFR > 90 mL/min per 1.73 m2) or mildly impaired (GFR 60–89 mL/min per 1.73 m2) renal function. Diastolic BPV was significantly lower in the mildly impaired renal function group. Regression analyses revealed a significant positive association between GFR and diastolic BPV for the entire study group. Plasma NO levels were significantly higher in the mildly impaired renal function group and negatively correlated with diastolic BPV. In conclusion, diastolic BPV was reduced in African Americans with mildly impaired renal function, which may be the result of increased NO production. These results conflict with previous findings in diseased and nonblack populations and could provide rationale for studying BPV early in the disease state when BP-buffering mechanisms are still preserved.

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EFFECTS OF INDUCIBLE NITRIC OXIDE SYNTHASE DEFICIENCY ON BLOOD PRESSURE VARIABILITY IN SEPTIC MICE

Critical Care Medicine ◽

10.1097/00003246-200212001-00183 ◽

2002 ◽

Vol 30 (Supplement) ◽

pp. A53

Author(s):

Steven M Hollenberg ◽

Joseph E Parrillo

Keyword(s):

Nitric Oxide ◽

Blood Pressure ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Blood Pressure Variability ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Rosuvastatin Decreases Caveolin-1 and Improves Nitric Oxide–Dependent Heart Rate and Blood Pressure Variability in Apolipoprotein E −/− Mice In Vivo

Circulation ◽

10.1161/01.cir.0000065601.83526.3e ◽

2003 ◽

Vol 107 (19) ◽

pp. 2480-2486 ◽

Cited By ~ 132

Author(s):

Michel Pelat ◽

Chantal Dessy ◽

Paul Massion ◽

Jean-Pierre Desager ◽

Olivier Feron ◽

...

Keyword(s):

Nitric Oxide ◽

Blood Pressure ◽

Heart Rate ◽

Apolipoprotein E ◽

Blood Pressure Variability ◽

Caveolin 1

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Mechanisms for the Development of Blood Pressure Variability and the Potential of Antihypertensive Drugs in Their Correction

Kardiologiia ◽

10.18087/cardio.2019.11.n803 ◽

2019 ◽

Vol 59 (11) ◽

pp. 56-65 ◽

Cited By ~ 1

Author(s):

A. I. Kochetkov ◽

O. D. Ostroumova ◽

E. V. Borisova ◽

G. F. Piksina

Keyword(s):

Nitric Oxide ◽

Blood Pressure ◽

Blood Pressure Variability ◽

Antihypertensive Drugs ◽

Pressure Fluctuations ◽

Clinical Importance ◽

Vascular Aging ◽

Excessive Pressure ◽

Nitric Oxide Deficiency ◽

Sympathetic Nervous

Blood pressure variability (BPV) is the fluctuations of blood pressure over a certain period of time under the influence of various factors. The issue of increased BPV is of particular clinical importance due to high predictive value of this parameter as a risk factor for fatal and non-fatal cardiovascular, cerebrovascular and renal events. It is proved that in the BPV increasing, the key role is played by impairments in arterial baroreflexes, which, in turn, are mediated by increased vascular stiffness, impact of angiotensin II and the sympathetic nervous system, endothelial dysfunction, nitric oxide deficiency and aging, including the vascular aging. Antihypertensive drugs that targeting largest amount of pathophysiological mechanisms in BPV increasing have a most advantages in correcting excessive pressure fluctuations. In this regard such drugs are perindopril and amlodipine, which can eliminate almost the entire spectrum of increased BPV causes and, therefore, optimally reduce the cardiovascular risk.

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