pressure fluctuations
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Author(s):  
Ahmed Ramadhan Al-Obaidi ◽  
Ali Qubian

Abstract In this current study, the transient numerical calculations using CFD code are carried out under different outlet impeller diameters for the flow field within a centrifugal pump under single-phase and cavitation conditions. Both qualitative and quantitative analyses are carried out on all of these results in order to better understand the flow structure within a centrifugal pump. Also, the investigations using different outlet impeller diameters configurations relating to the static pressure, velocity magnitude, vapour volume fraction variations, as well as pressure fluctuations in both time and frequency domain at the impeller and volute of the pump are analysed. Velocity and static pressure variations of the pump under different outlet impeller diameters range (200, 210 and 220 mm) are investigated. Reliable model is developed and validated, at various pump operating conditions, to analyse the characteristics of pressure fluctuations in both time and frequency domain. Cavitation occurrence, under different outlet impeller diameters and flow rates, are detected and correlated, using a CFD model (volume fraction distributions). Based on the developed model’s findings, at the set operating conditions ranges, the distribution and impact (cavitation and head-wises) of both the pressure and velocity are analysed. The average pressure fluctuation in the volute for do = 210 mm is higher than for do = 200 mm by about 6.74%, also the maximum pressure fluctuation for do = 220 mm is higher than for do = 210 mm by around 7.4%. Furthermore, the maximum pressure fluctuation in the impeller for do = 210 mm is higher than for do = 200 mm by 12.48%, also for do = 220 mm is higher than for do = 210 mm by 10.8%. The developed CFD models are proved valuable tools in identifying and optimizing the pump performance and characterization. The head for when do = 220 mm is higher than for when do = 200 mm under both single-phase and cavitation conditions by around 14.13% and 14.69%. The maximum pressure fluctuation for do = 200 mm is lower than for do = 210 mm by 41.58%. Furthermore, the maximum pressure fluctuation at the impeller for do = 220 mm is higher than the two models. There is a small clearance between the impeller and the volute for this model, leading to the pressure fluctuation amplitudes being higher than the other above models.


Author(s):  
Yan Longlong ◽  
Bo Gao ◽  
Dan Ni ◽  
Ning Zhang ◽  
Wenjie Zhou

Abstract To accurately capture the behaviors of cavitation and reveal the unsteady cavitating flow mechanism, a condensate pump inducer is numerically analyzed in a separate numerical experiment with LES at critical cavitation number sind,c under the design point. Based on the new Omega vortex identification method, the correction between the flow structures and cavities is clearly illustrated. Besides, the pressure fluctuations around the inducer are analyzed. Special emphasis is put on the analysis of the interactions between the cavities, turbulent fluctuations, and vortical flow structures. The Omega vortex identification method could give an overall picture of the whole cavitating flow structures to present a clear correlation between the vortices and cavities. The results show that the shear cavitation dominant the cavitation characteristics under the design point. The pure rigid rotation region mainly concentrates at the edge of the cavities while the other sheet-like cavities near the casing walls are characterized by strong turbulence fluctuations. Besides, based on the analysis of the correlation between the cavities and flow structures, the rotating cavitation under the design point may mainly attribute to the interaction between the tip leakage vortex cavitation and the next blade.


Fluids ◽  
2022 ◽  
Vol 7 (1) ◽  
pp. 28
Author(s):  
Ruichen Li ◽  
Koichi Sughimoto ◽  
Xiancheng Zhang ◽  
Sirui Wang ◽  
Yuto Hiraki ◽  
...  

To explore hemodynamic interaction between the human respiratory system (RS) and cardiovascular system (CVS), here we propose an integrated computational model to predict the CVS hemodynamics with consideration of the respiratory fluctuation (RF). A submodule of the intrathoracic pressure (ITP) adjustment is developed and incorporated in a 0-1D multiscale hemodynamic model of the CVS specified for infant, adolescent, and adult individuals. The model is verified to enable reasonable estimation of the blood pressure waveforms accounting for the RF-induced pressure fluctuations in comparison with clinical data. The results show that the negative ITP caused by respiration increases the blood flow rates in superior and inferior vena cavae; the deep breathing improves the venous return in adolescents but has less influence on infants. It is found that a marked reduction in ITP under pathological conditions can excessively increase the flow rates in cavae independent of the individual ages, which may cause the hemodynamic instability and hence increase the risk of heart failure. Our results indicate that the present 0-1D multiscale CVS model incorporated with the RF effect is capable of providing a useful and effective tool to explore the physiological and pathological mechanisms in association with cardiopulmonary interactions and their clinical applications.


2022 ◽  
Author(s):  
Mario E Di Salvo ◽  
Kimberly A Reynolds ◽  
Milo M Lin

Two functional protein sequences can sometimes be separated by a fitness valley - a series of low or non-functional intermediate mutations that must be traversed to reach a more optimal or refined function. Time-varying selection pressure modulates evolutionary sampling of such valleys. Yet, how the amplitude and frequency of fluctuating selection influence the rate of protein evolution is poorly understood. Here, we derive a simple equation for the time-dependent probability of crossing a fitness valley as a function of evolutionary parameters: valley width, protein size, mutation rate, and selection pressure. The equation predicts that, under low selection pressure, the valley crossing rate is magnified by a factor that depends exponentially on valley width. However, after a characteristic time set by the evolutionary parameters, the rate rapidly decays. Thus, there is an optimal frequency of selection-pressure fluctuations that maximizes the rate of protein optimization. This result is reminiscent of the resonance frequency in mechanical systems. The equation unites empirical and theoretical results that were previously disconnected, and is consistent with time-dependent in vitro and clinical data. More generally, these results suggest that seasonal and climate oscillations could synchronously drive protein evolution at the resonant frequency across a range of organism hosts and timescales. This theory could also be applied to optimize de novo protein evolution in laboratory directed evolution using time-varying protocols.


2022 ◽  
Author(s):  
Yasuhiro Egami ◽  
Masashi Takizawa ◽  
Saki Watanabe ◽  
Yu Matsuda

Machines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Xiumei Liu ◽  
Jie He ◽  
Yongwei Xie ◽  
Beibei Li ◽  
Yujia Zhang ◽  
...  

A multi-field synchronous measurement system for the cavitation flow in a regulating valve was established. The system combines a high-speed full-flow field display system with a pressure measurement system to realize the simultaneous acquisition of cavitation shapes and pressure pulsations. Cavitation flow occurs near the throttle orifice, which is obviously a quasi-periodic behavior. The unsteady cavitation flow mainly includes three stages: the growth of the attached cavity, the fracture and shedding of the attached cavity and the growth and collapse of the free cavity. The time evolution of the cavitation behaviors is highly related with excited pressure fluctuations. With the increasing attached cavity area, the corresponding pressure in the flow field decreases slowly. When the attached cavity falls off and develops downstream, the cavity area decreases gradually, and the pressure increases gradually. When the free cavity shrinks and collapses, the pressure in the flow field reaches the peak value. The pressure pulsation and the change of cavity area have the same dominant frequency, around 2000 Hz, at the monitoring point in the upstream, throat and expansion monitoring points. Furthermore, with increasing inlet pressure, the mean and variance values of cavitation area become larger, and the excited pressure fluctuation at each measuring point becomes more intense. The mean value of pulsating pressure at the throat gradually increases, while the pressure in the expansion section presents a downward trend. The variance of pressure pulsation and the maximum pressure also increase gradually with the increase in inlet pressure. The change of cavitation area and the pressure pulsation in the regulating valve complement each other. The results in this paper could provide experimental guidance on optimizing the structure of the valve, inhibiting cavitation occurrence and prolonging the service life of the valve.


2021 ◽  
Vol 14 (4) ◽  
pp. 410-416
Author(s):  
Maria Łukasiewicz ◽  
Artur Mamcarz

1.28 billion people suffer from hypertension, and its complications cause 10 million deaths each year. Effective antihypertensive therapy is therefore one of the priority tasks of health care. Achieving good BP control depends on many factors, but one of the primary ones is the use of maximally effective therapy in the simplest possible regimen. Amlodipine in combination with telmisartan in the single-pill combination, through its high smoothness index, makes it possible to achieve a satisfactory hypotensive effect lasting 24 h when taken once daily. This combination is also a good alternative for cardiovascularly burdened patients who cannot use angiotensin-converting enzyme inhibitors and for elderly patients, especially after stroke


Author(s):  
Zhengfeng Liu ◽  
Hui Yang ◽  
Haijiang He ◽  
Peiquan Yu ◽  
Yikun Wei ◽  
...  

The characteristics of internal flow and performance of a centrifugal fan is greatly dependent on the inflow pattern. As the fan is subjected to incoming flow from an upstream tube, the size and geometry of the tube affect the three-dimensional motion of local flow and possibly degrades the aerodynamic performance of the fan. In this work, we performed a numerical investigation on the internal flow in a centrifugal fan subjected to incoming flow from an upstream bended inflow tube of various radii using the steady and unsteady Reynolds-averaged Navier-Stokes (RANS and URANS) simulation approaches. The effects of the non-axisymmetric pre-swirl flow generated due to the curvature of the bended inflow tube are demonstrated by analyzing the internal flow characteristics of the fan, including the spatial distributions and temporal variations of pressure field and streamlines, pressure fluctuations in the upstream tube, the inflow and outflow sections of the impeller, and the circumferential distributions of velocity and pressure in the impeller. The numerical results reveal that as the inflow tube is curved with larger curvature (smaller radius of the bended section), the pre-swirl inflow is strong and deteriorates the static pressure rise and static pressure efficiency of the centrifugal fan more remarkably, and the circumferential non-uniformity of pressure and velocity distributions appears inside of the channels of the fan. As the radius of the bended section increases, the instability of the internal flow gets more pronounced, as represented by the stronger pressure fluctuations at the inflow and outflow sections. The prediction capabilities of RANS and URANS approaches are also analyzed based on the numerical data and we found that the latter is more reliable in predicting the performance of the fan.


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