Elevated titers of cell-free interleukin-2 receptor in serum and cerebrospinal fluid specimens of patients with acquired immunodeficiency syndrome

1986 ◽  
Vol 13 (4) ◽  
pp. 179-184 ◽  
Author(s):  
K.K. Sethi ◽  
H. Näher
Keyword(s):  
Cerebrospinal Fluid ◽  
Acquired Immunodeficiency Syndrome ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Intralymphatic Interleukin 2 Treatment in Patients with Acquired Immunodeficiency Syndrome: Preliminary Experience in Three Cases

Immunobiology ◽  
1986 ◽  
Vol 172 (3-5) ◽  
pp. 438-447 ◽  
Author(s):  
M. Gramatzki ◽  
H. Nüsslein ◽  
G.R. Burmester ◽  
W. Rüdl ◽  
N. Heyder ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Interleukin 2 ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

scholarly journals Bacterial agents isolated from cerebrospinal fluid of patients with Acquired Immunodeficiency Syndrome (AIDS) and neurological complications

1994 ◽  
Vol 36 (6) ◽  
pp. 491-496 ◽  
Author(s):  
Ilka Maria Landgraf ◽  
Moisés Palaci ◽  
Maria de Fátima Paiva Vieira ◽  
Sueli Yoko Mizuka Ueki ◽  
Maria Conceição Martins ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Acquired Immunodeficiency Syndrome ◽  
Mycobacterium Avium Complex ◽  
Neurological Complications ◽  
Age Group ◽  
Bacterial Agent ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
And Staphylococcus Aureus ◽  
Culture Positive

Cerebrospinal fluid (CSF) samples from 2083 patients with acquired immunodeficiency syndrome (AIDS) and neurological complications were bacteriologically examined during a period of 7 years (1984-1990). The percentage of patients who had at least one bacterial agent cultured from the CSF was 6.2%. Mycobacterium tuberculosis was the most frequently isolated agent (4.3%), followed by Mycobacterium avium complex or MAC (0.7%), Pseudomonas spp (0.5%), Enterobacter spp (0.4%), and Staphylococcus aureus (0.3%). Among 130 culture positive patients, 89 (68.5%) had M. tuberculosis and 15 (11.6%) had MAC. The frequency of bacterial isolations increased from 1988 (5.2%) to 1990 (7.2%), partly due to the increase in MAC isolations. Bacterial agents were more frequently isolated from patients in the age group 21-30 years and from women (p<0.05).

scholarly journals CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy.

1992 ◽  
Vol 175 (6) ◽  
pp. 1589-1599 ◽  
Author(s):  
G Muralidhar ◽  
S Koch ◽  
M Haas ◽  
S L Swain
Keyword(s):  
T Cells ◽  
T Cell ◽  
Acquired Immunodeficiency Syndrome ◽  
Cd4 T Cells ◽  
Interleukin 2 ◽  
Cell Subset ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Phenotypic Shift ◽  
Kinetics Of

We have examined the kinetics of changes that occur in the helper T cell subset during murine acquired immunodeficiency syndrome, which occurs after infection with the mix of viruses known as BM5. We find that there is expansion of the CD4 T cells by 2 wk, 50% of the CD4 T cells become large as the disease progresses, and the CD4 T cell population is increasingly comprised of cells with a memory/activated phenotype. These effects are apparent by 2 wk postinfection, and the change is nearly complete by 6-8 wk. The phenotypic shift is paralleled by the loss of the ability of the CD4 T cells to proliferate or to produce interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma in response to stimulation with mitogens, superantigen, or anti-CD3. There is no obvious expansion or deletion of CD4 T cells expressing particular V beta genes, as might be expected if a conventional superantigen were driving the changes. The results suggest, however, that the total CD4 population has been driven to anergy by some potent polyclonal stimulus directly associated with viral infection.

scholarly journals Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome.

1985 ◽  
Vol 76 (5) ◽  
pp. 1959-1964 ◽  
Author(s):  
H W Murray ◽  
K Welte ◽  
J L Jacobs ◽  
B Y Rubin ◽  
R Mertelsmann ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Interleukin 2 ◽  
In Vitro Response ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome
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