Sequence of centromere division in bone marrow cells of patients with chronic myelocytic leukemia

1986 ◽  
Vol 21 (1) ◽  
pp. 31-33
Author(s):  
Katalin Bajnóczky
Blood ◽  
1977 ◽  
Vol 49 (3) ◽  
pp. 367-370 ◽  
Author(s):  
DW Golde ◽  
C Burgaleta ◽  
RS Sparkes ◽  
MJ Cline

Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed. All cell metaphases examined contained the Ph1 chromosome at a time when more than 80% of these metaphases were in identifiable macrophages. We conclude that the mononuclear phagocyte cell line contains the abnormal chromosome in Ph1-positive chronic myelocytic leukemia.


2008 ◽  
Vol 15 (4) ◽  
pp. 327-331 ◽  
Author(s):  
Lillian Y. F. Hsu ◽  
Michael L. Greenberg ◽  
Simona Kohan ◽  
Ruth Wittman

Blood ◽  
1977 ◽  
Vol 49 (3) ◽  
pp. 367-370 ◽  
Author(s):  
DW Golde ◽  
C Burgaleta ◽  
RS Sparkes ◽  
MJ Cline

Abstract Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed. All cell metaphases examined contained the Ph1 chromosome at a time when more than 80% of these metaphases were in identifiable macrophages. We conclude that the mononuclear phagocyte cell line contains the abnormal chromosome in Ph1-positive chronic myelocytic leukemia.


2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
C Stamm ◽  
YH Choi ◽  
A Liebold ◽  
HD Kleine ◽  
S Dunkelmann ◽  
...  

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