In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance in experimental allergic neuritis

1989 ◽  
Vol 23 (1) ◽  
pp. 11-18 ◽  
Author(s):  
K. Strigård ◽  
P. Larsson ◽  
R. Holmdahl ◽  
L. Klareskog ◽  
T. Olsson
Keyword(s):  
Monoclonal Antibody ◽  
Experimental Allergic Neuritis ◽  
Disease Relapse ◽  
Antibody Treatment ◽  
Monoclonal Antibody Treatment ◽  
Experimental Allergic ◽  
Allergic Neuritis

scholarly journals The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory Molecules

2002 ◽  
Vol 76 (24) ◽  
pp. 13106-13110 ◽  
Author(s):  
Kathy A. Green ◽  
W. James Cook ◽  
Arlene H. Sharpe ◽  
William R. Green
Keyword(s):  
Monoclonal Antibody ◽  
B Cells ◽  
Molecular Interactions ◽  
T And B Cells ◽  
Antibody Treatment ◽  
Monoclonal Antibody Treatment ◽  
Murine Aids ◽  
Cd40 Expression ◽  
Immunodeficiency Syndrome

ABSTRACT C57BL/6 (B6) mice infected with LP-BM5 retroviruses develop disease, including an immunodeficiency similar to AIDS. This disease, murine AIDS (MAIDS), is inhibited by in vivo anti-CD154 monoclonal antibody treatment. The similar levels of insusceptibility of CD40−/− and CD154−/− B6 mice indicate that CD154/CD40 molecular interactions are required for MAIDS. CD4+ T and B cells, respectively, provide the CD154 and CD40 expression needed for MAIDS induction. Here, the required CD154/CD40 interaction is shown to be independent of CD80 and CD86 expression: CD80/CD86−/− B6 mice develop MAIDS after LP-BM5 infection.

Effects on Experimental Allergic Neuritis in Rats by in Vivo Treatment with Monoclonal Anti-T-Cell Antibodies

1988 ◽  
Vol 540 (1 Advances in N) ◽  
pp. 560-562
Author(s):  
T. OLSSON ◽  
K. STRIGARD ◽  
P. LARSSON ◽  
R. HOLMDAHL ◽  
L. KLARESKOG
Keyword(s):  
T Cell ◽  
Experimental Allergic Neuritis ◽  
In Vivo Treatment ◽  
Experimental Allergic ◽  
Allergic Neuritis

Modulation of experimental allergic neuritis in rats by in vivo treatment with monoclonal anti T cell antibodies

1988 ◽  
Vol 83 (2-3) ◽  
pp. 283-291 ◽  
Author(s):  
Karin Strigård ◽  
Tomas Olsson ◽  
Per Larsson ◽  
Rikard Holmdahl ◽  
Lars Klareskog
Keyword(s):  
T Cell ◽  
Experimental Allergic Neuritis ◽  
In Vivo Treatment ◽  
Experimental Allergic ◽  
Allergic Neuritis
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