Lack of effect of lesions in the anterior cingulate cortex and retrosplenial cortex on certain tests of spatial memory in the rat

1994 ◽  
Vol 65 (1) ◽  
pp. 89-101 ◽  
Author(s):  
N. Neave ◽  
S. Lloyd ◽  
A. Sahgal ◽  
J.P. Aggleton
2019 ◽  
Author(s):  
Mordechai Hayman ◽  
Shahar Arzy

“Mental travel” is the ability to imagine oneself in different places and times and to adopt other people’s point of view (POV), also termed “Theory of Mind (ToM)”. While ToM has been extensively investigated, self-projection with respect to ones’ own and others’ social networks has yet to be systematically studied.Here we asked participants to “project” themselves to four different POVs: a significant other, a non-significant other, a famous-person, and their own-self. From each POV they were asked to rate the level of affiliation (closeness) to different individuals in the respective social network while undergoing functional MRI.Participants were always faster making judgments from their own POV compared to other POVs (self-projection effect) and for people who were personally closer to their adopted POV (self-reference effect). Brain activity at the medial prefrontal and anterior cingulate cortex in the self POV condition was found to be higher compared to all other conditions. Activity at the right temporoparietal junction and medial parietal cortex was found to distinguish between the personally related (self, significant- and non-significant others) and unrelated (famous-person) individuals within the social network. Regardless of the POV, the precuneus, anterior cingulate cortex, prefrontal cortex, and temporoparietal junction distinguished between relatively closer and distant people. Representational similarity analysis (RSA) implicated the left retrosplenial cortex as crucial for social distance processing across all POVs.


2006 ◽  
Vol 26 (29) ◽  
pp. 7555-7564 ◽  
Author(s):  
C. M. Teixeira ◽  
S. R. Pomedli ◽  
H. R. Maei ◽  
N. Kee ◽  
P. W. Frankland

Author(s):  
Mordechai Hayman ◽  
Shahar Arzy

"Mental travel" is a cognitive concept embodying the human capacity to intentionally disengage from the here and now, and mentally experience the world from different perspectives. We explored how individuals mentally "travel" to the point-of-view (POV) of other people in varying levels of personal closeness and from these perspectives process these people's social network. Under fMRI, participants were asked to "project" themselves to the POVs of four different people: a close other, a non-close other, a famous-person, and their own-self, and rate the level of affiliation (closeness) to different individuals in the respective social network. Participants were always faster making judgments from their own POV compared to other POVs (self-projection effect) and for people who were personally closer to their adopted POV (social-distance effect). Brain activity at the medial prefrontal and anterior cingulate cortex in the self-POV was higher, compared to all other conditions. Activity at the right temporoparietal junction and medial parietal cortex was found to distinguish between the personally related (self, close and non-close others) and unrelated (famous-person) people. No difference was found between mental travel to the POVs of close and non-close others. Regardless of POV, the precuneus, anterior cingulate cortex, prefrontal cortex, and temporoparietal junction distinguished between close and distant individuals within the different social networks. Representational similarity analysis implicated the left retrosplenial cortex as crucial for social distance processing across all POVs. These distinctions suggest several constraints regarding our ability to adopt others' POV, and process not only ours but also other people's social networks.


2021 ◽  
pp. 1-10
Author(s):  
Megan E. Monko ◽  
Sarah R. Heilbronner

Abstract Previous studies of the retrosplenial cortex (RSC) have focused on its role in navigation and memory, consistent with its well-established medial temporal connections, but recent evidence also suggests a role for this region in reward and decision making. Because function is determined largely by anatomical connections, and to better understand the anatomy of RSC, we used tract-tracing methods to examine the anatomical connectivity between the rat RSC and frontostriatal networks (canonical reward and decision-making circuits). We find that, among frontal cortical regions, RSC bidirectionally connects most strongly with the anterior cingulate cortex, but also with an area of the central–medial orbito-frontal cortex. RSC projects to the dorsomedial striatum, and its terminal fields are virtually encompassed by the frontal-striatal projection zone, suggestive of functional convergence through the basal ganglia. This overlap is driven by anterior cingulate cortex, prelimbic cortex, and orbito-frontal cortex, all of which contribute to goal-directed decision making, suggesting that the RSC is involved in similar processes.


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