Bombesin: Central nervous system actions to affect the autonomic nervous system

1987 ◽  
Vol 19 (1-2) ◽  
pp. 102 ◽  
Author(s):  
MarvinR. Brown ◽  
Jean Rivier ◽  
Laurel Fisher
2021 ◽  
Author(s):  
Asif Hasan Sharif

The fractal component in the complex fluctuations of the human heart rate represents a dynamic feature that is widely observed in diverse fields of natural and artificial systems. It is also of clinical significance as the diminishing of the fractal dynamics appears to correlate with heart disease processes and adverse cardiac events in old age. While the autonomic nervous system directly controls the pacemaker cells of the heart, it does not provide an immediate characterization of the complex heart rate variability (HRV). The central nervous system (CNS) is known to be an important modulator for various cardiac functions. However, its role in the fractal HRV is largely unclear. In this research, human experiments were conducted to study the influence of the central nervous system on fractal dynamics of healthy human HRV. The head up tilt (HUT) maneuver is used to provide a perturbation to the autonomic nervous system. The subsequent fractal effect in the simultaneously recorded electroencephalography and beat-to-beat heart rate data was examined. Using the recently developed multifractal factorization technique, the common multifractality in the data fluctuation was analyzed. An empirical relationship was uncovered which shows the increase (decrease) in HRV multifractality is associated with the increase (decrease) in multifractal correlation between scale-free HRV and the cortical expression of the brain dynamics in 8 out of 11 healthy subjects. This observation is further supported using surrogate analysis. The present findings imply that there is an integrated central-autonomic component underlying the cortical expression of the HRV fractal dynamics. It is proposed that the central element should be incorporated in the fractal HRV analysis to gain a more comprehensive and better characterization of the scale-free HRV dynamics. This study provides the first contribution to the HRV multifractal dynamics analysis in HUT. The multivariate fractal analysis using factorization technique is also new and can be applied in the more general context in complex dynamics research.


Author(s):  
Kevin T. Gobeske ◽  
Eelco F. M. Wijdicks

Serotonin syndrome affects the central nervous system, the autonomic nervous system, and the neuromuscular system and can have acute and potentially life-threatening manifestations. By definition, serotonin syndrome is associated with changes in serotonin exposure and thus might be described more accurately as serotonergic excess or serotonin toxicity. The central nervous system effects of serotonin involve regulation of attention, arousal, mood, learning, appetite, and temperature.


CNS Spectrums ◽  
2007 ◽  
Vol 12 (8) ◽  
pp. 625-634 ◽  
Author(s):  
David S. Shannahoff-Khalsa

ABSTRACTResearch advances have led to three methods for selectively activating one half of the autonomic nervous system in humans.The first method is an ancient yogic technique called unilateral forced nostril breathing (UFNB) that employs forced breathing through only one nostril while closing off the other. The second method works by stimulation of an autonomic reflex point on the fifth intercostal space near the axilla. The most recent method employs unilateral vagus nerve stimulation (VNS) via the mid-inferior cervical branch and requires surgical implantation of a wire and pacemaker. UFNB is non-invasive and seems to selectively activate the ipsilateral branch of the sympathetic nervous system with a possible compensation effect leading to contralateral VNS. UFNB and VNS have been employed to treat psychiatric disorders. While UFNB has been studied for its potential effects on the endogenous ultradian rhythms of the autonomic and central nervous system, and their tightly coupled correlates, VNS has yet to be studied in this regard. This article reviews these three methods and discusses their similarities, putative mechanisms, their studied effects on the endogenous autonomic nervous system and central nervous system rhythms, and their implications for the treatment of psychiatric disorders.


1974 ◽  
Vol 5 (4) ◽  
pp. 517-529 ◽  
Author(s):  
William F. Kiely

The neurobiological basis of psychopathology is surveyed with emphasis upon reciprocal balances between opposing ergotropic and trophotropic systems with their central nervous system (CNS), autonomic nervous system (ANS) and neuroendocrine components. The anatomical sites, neurophysiological interconnections, and neurochemical transmitters which subserve functions of arousal, attention, perception, motion, emotion, memory, and learning are outlined. Mechanisms whereby disorders of psychophysiologic, somatopsychic and classically organic type may be triggered through such neurobiological pathways are suggested.


2021 ◽  
Vol 32 (4) ◽  
pp. 299-302
Author(s):  
A. I. Smirnov ◽  
L. D. Olefirenko

In our laboratory, much attention is paid to the effect of morphine on dogs, since its use made it possible to establish extremely important facts that brought a lot of clarity to the study of the relationship between meleda by the autonomic nervous system and the activity of the cerebral cortex.


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