FEATURES OF THE AUTONOMIC NERVOUS SYSTEM IN CHILDREN WITH PERINATAL PATHOLOGY OF THE CENTRAL NERVOUS SYSTEM

Author(s):  
S.V. Plakhotnikova ◽  
◽  
G.V. Santalova ◽  
E.S. Gasilina ◽  
◽  
...  
2021 ◽  
Author(s):  
Asif Hasan Sharif

The fractal component in the complex fluctuations of the human heart rate represents a dynamic feature that is widely observed in diverse fields of natural and artificial systems. It is also of clinical significance as the diminishing of the fractal dynamics appears to correlate with heart disease processes and adverse cardiac events in old age. While the autonomic nervous system directly controls the pacemaker cells of the heart, it does not provide an immediate characterization of the complex heart rate variability (HRV). The central nervous system (CNS) is known to be an important modulator for various cardiac functions. However, its role in the fractal HRV is largely unclear. In this research, human experiments were conducted to study the influence of the central nervous system on fractal dynamics of healthy human HRV. The head up tilt (HUT) maneuver is used to provide a perturbation to the autonomic nervous system. The subsequent fractal effect in the simultaneously recorded electroencephalography and beat-to-beat heart rate data was examined. Using the recently developed multifractal factorization technique, the common multifractality in the data fluctuation was analyzed. An empirical relationship was uncovered which shows the increase (decrease) in HRV multifractality is associated with the increase (decrease) in multifractal correlation between scale-free HRV and the cortical expression of the brain dynamics in 8 out of 11 healthy subjects. This observation is further supported using surrogate analysis. The present findings imply that there is an integrated central-autonomic component underlying the cortical expression of the HRV fractal dynamics. It is proposed that the central element should be incorporated in the fractal HRV analysis to gain a more comprehensive and better characterization of the scale-free HRV dynamics. This study provides the first contribution to the HRV multifractal dynamics analysis in HUT. The multivariate fractal analysis using factorization technique is also new and can be applied in the more general context in complex dynamics research.


Author(s):  
Kevin T. Gobeske ◽  
Eelco F. M. Wijdicks

Serotonin syndrome affects the central nervous system, the autonomic nervous system, and the neuromuscular system and can have acute and potentially life-threatening manifestations. By definition, serotonin syndrome is associated with changes in serotonin exposure and thus might be described more accurately as serotonergic excess or serotonin toxicity. The central nervous system effects of serotonin involve regulation of attention, arousal, mood, learning, appetite, and temperature.


2021 ◽  
Vol 32 (4) ◽  
pp. 299-302
Author(s):  
A. I. Smirnov ◽  
L. D. Olefirenko

In our laboratory, much attention is paid to the effect of morphine on dogs, since its use made it possible to establish extremely important facts that brought a lot of clarity to the study of the relationship between meleda by the autonomic nervous system and the activity of the cerebral cortex.


2019 ◽  
Vol 72 (1) ◽  
pp. 120-123
Author(s):  
Beata Łabuz-Roszak ◽  
Iwona Mańka-Gaca

Generalized or partial epileptic seizures may be accompanied by autonomic dysfunction. They may also take the form of self-inflicted seizures or be present during interictal period. Arrhythmias, resulting in haemodynamic disturbances in the circulatory system and prolonged hypoxia of the central nervous system, may itself provoke secondary episodes of seizure morphology. The doctor when diagnosing patients with epileptic seizures should always be aware of the potential for cardiogenic disorders. Consideration should be given to the effect of epilepsy on the structure of the autonomic nervous system, the effect of antiepileptic drugs, and the potential for mutations within the ion channels.


PEDIATRICS ◽  
1951 ◽  
Vol 7 (4) ◽  
pp. 529-536
Author(s):  
L. W. SENNETT ◽  
M. A. PERLSTEIN ◽  
M. B. ANDELMAN ◽  
H. E. BARNETT ◽  
H. JOSEPHY

A case of sustained hypertension complicating acute protracted poliomyelitis with respiratory involvement is presented. Data of studies of the autonomic nervous system and the kidneys are given. Complete necropsy findings, including detailed examination of the central nervous system, are presented. The role played by the nervous system and kidney is discussed, and it is suggested that in this case the hypertension probably was due to neurogenic factors.


1936 ◽  
Vol 32 (8) ◽  
pp. 1032-1032
Author(s):  
S. Geller

The authors point out that nocturia cannot be considered a simple disorder of the discharge cycle: according to a number of their personal observations, it is a symptom of a disorder of the central nervous system.


2021 ◽  
Author(s):  
Asif Hasan Sharif

The fractal component in the complex fluctuations of the human heart rate represents a dynamic feature that is widely observed in diverse fields of natural and artificial systems. It is also of clinical significance as the diminishing of the fractal dynamics appears to correlate with heart disease processes and adverse cardiac events in old age. While the autonomic nervous system directly controls the pacemaker cells of the heart, it does not provide an immediate characterization of the complex heart rate variability (HRV). The central nervous system (CNS) is known to be an important modulator for various cardiac functions. However, its role in the fractal HRV is largely unclear. In this research, human experiments were conducted to study the influence of the central nervous system on fractal dynamics of healthy human HRV. The head up tilt (HUT) maneuver is used to provide a perturbation to the autonomic nervous system. The subsequent fractal effect in the simultaneously recorded electroencephalography and beat-to-beat heart rate data was examined. Using the recently developed multifractal factorization technique, the common multifractality in the data fluctuation was analyzed. An empirical relationship was uncovered which shows the increase (decrease) in HRV multifractality is associated with the increase (decrease) in multifractal correlation between scale-free HRV and the cortical expression of the brain dynamics in 8 out of 11 healthy subjects. This observation is further supported using surrogate analysis. The present findings imply that there is an integrated central-autonomic component underlying the cortical expression of the HRV fractal dynamics. It is proposed that the central element should be incorporated in the fractal HRV analysis to gain a more comprehensive and better characterization of the scale-free HRV dynamics. This study provides the first contribution to the HRV multifractal dynamics analysis in HUT. The multivariate fractal analysis using factorization technique is also new and can be applied in the more general context in complex dynamics research.


2016 ◽  
Vol 97 (4) ◽  
pp. 598-606 ◽  
Author(s):  
V N Shvalev ◽  
V P Reutov ◽  
V B Sergienko ◽  
A N Rogoza ◽  
V P Masenko ◽  
...  

Prospects for the development of the nervism doctrine in Kazan are related to the continuation of the main scientific fields specific to Kazan medical schools - studying phylo-ontogenesis of the nervous system and the importance of its violations in the development of main diseases using the latest methods. The age-related transformations of the human cardiovascular system innervation in the pre- and postnatal ontogenesis in normal conditions and in major cardiovascular diseases are under study. It was found that the relationship between the human brain and heart during the first 30-40 years of life are characterized by optimally high activity, but then, along with age-related changes in the neurons of the central nervous system there is a decrease in activity of the somatic part of the peripheral nervous system. As morphofunctional studies showed, it is partially related to a decrease in the content of neurotransmitters in the sympathetic plexus of the heart and blood vessels. A concept on the mediator stage of the autonomic nervous system ontogenesis is formulating, it was revealed that the fetal period, along with the differentiation of the central nervous system, is characterized by the beginning of mediator stage of the autonomic nervous system, the phenomenon of early involution of its sympathetic part in normal conditions and in different types of cardiovascular pathology is described. Neurohistochemical data are compared with the results of heart rate variability in healthy individuals and in hypertensive disease. The original data on the nitric oxide synthase content in cardiac nervous system in healthy individuals and in ischemic heart disease are given, the prospects of immunocytochemistry studies of central and peripheral nervous system in age aspect and in major cardiovascular diseases are outlined.


2007 ◽  
Vol 88 (3) ◽  
pp. 1048-1055 ◽  
Author(s):  
Christine Hoffmann ◽  
Ute Ziegler ◽  
Anne Buschmann ◽  
Artur Weber ◽  
Leila Kupfer ◽  
...  

To elucidate the still-unknown pathogenesis of bovine spongiform encephalopathy (BSE), an oral BSE challenge and sequential kill study was carried out on 56 calves. Relevant tissues belonging to the peripheral and central nervous system, as well as to the lymphoreticular tract, from necropsied animals were analysed by highly sensitive immunohistochemistry and immunoblotting techniques to reveal the presence of BSE-associated pathological prion protein (PrPSc) depositions. Our results demonstrate two routes involving the autonomic nervous system through which BSE prions spread by anterograde pathways from the gastrointestinal tract (GIT) to the central nervous system (CNS): (i) via the coeliac and mesenteric ganglion complex, splanchnic nerves and the lumbal/caudal thoracic spinal cord (representing the sympathetic GIT innervation); and (ii) via the Nervus vagus (parasympathetic GIT innervation). The dorsal root ganglia seem to be subsequently affected, so it is likely that BSE prion invasion of the non-autonomic peripheral nervous system (e.g. sciatic nerve) is a secondary retrograde event following prion replication in the CNS. Moreover, BSE-associated PrPSc was already detected in the brainstem of an animal 24 months post-infection, which is 8 months earlier than reported previously. These findings are important for the understanding of BSE pathogenesis and for the development of new diagnostic strategies for this infectious disease.


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