Differences in the potency of CP-96,345 and RP-67,580, two new non-peptide antagonists selective for NK1 receptors, in inhibiting responses evoked by stimulation of sensory nerves

1992 ◽  
Vol 37 ◽  
pp. S52
Author(s):  
P. Delay-Goyet ◽  
H. Satoh ◽  
J.M. Lundberg
Keyword(s):  
Sensory Nerves ◽  
Nk1 Receptors ◽  
Stimulation Of

Differences in the potency o non-peptide antagonists selective for NK1 receptors, in inhibiting responses evoked by stimulation of sensory nerves

1993 ◽  
Vol 46 (1-2) ◽  
pp. 304-306 ◽  
Author(s):  
Philippe Delay-Goyet ◽  
Hiroyuki Satoh ◽  
Per Stjärne ◽  
Johan Rinder ◽  
Jan M. Lundberg
Keyword(s):  
Sensory Nerves ◽  
Nk1 Receptors ◽  
Stimulation Of

A Novel α-Conotoxin Identified by Gene Sequencing Is Active in Suppressing the Vascular Response to Selective Stimulation of Sensory Nerves in Vivo†

Biochemistry ◽  
2003 ◽  
Vol 42 (22) ◽  
pp. 6904-6911 ◽  
Author(s):  
D. W. Sandall ◽  
N. Satkunanathan ◽  
D. A. Keays ◽  
M. A. Polidano ◽  
X. Liping ◽  
...  
Keyword(s):  
Gene Sequencing ◽  
Sensory Nerves ◽  
Vascular Response ◽  
Selective Stimulation ◽  
Stimulation Of

Effect of neuropeptides released from sensory nerves on blood flow in the rat airway microcirculation

1992 ◽  
Vol 72 (4) ◽  
pp. 1563-1570 ◽  
Author(s):  
G. Piedimonte ◽  
J. I. Hoffman ◽  
W. K. Husseini ◽  
W. L. Hiser ◽  
J. A. Nadel
Keyword(s):  
Blood Flow ◽  
Substance P ◽  
Regional Blood Flow ◽  
Reference Sample ◽  
Left Ventricular ◽  
Sensory Nerves ◽  
Microvascular Blood Flow ◽  
Systemic Injection ◽  
Airway Mucosa ◽  
Stimulation Of

Stimulation of sensory nerves in the airway mucosa causes local release of the neuropeptides substance P and calcitonin gene-related peptide (CGRP). In this study we used a modification of the reference-sample microsphere technique to measure changes in regional blood flow and cardiac output distribution produced in the rat by substance P, CGRP, and capsaicin (a drug that releases endogenous neuropeptides from sensory nerves). Three sets of microspheres labeled with different radionuclides were injected into the left ventricle of anesthetized F344 rats before, immediately after, and 5 min after left ventricular injections of capsaicin, substance P, or CGRP. The reference blood sample was withdrawn from the abdominal aorta and was simultaneously replaced with 0.9% NaCl at 37 degrees C. We found that stimulation of sensory nerves with a low dose of capsaicin causes a large and selective increase in microvascular blood flow in the extrapulmonary airways. The effect of capsaicin is mimicked by systemic injection of substance P but not by CGRP, suggesting that substance P is the main agent of neurogenic vasodilation in rat airways.

scholarly journals Physiological characterisation of antennal mechanosensory descending interneurons in an insect (Gryllus bimaculatus, Gryllus campestris) brain

2001 ◽  
Vol 204 (13) ◽  
pp. 2265-2275 ◽  
Author(s):  
Michael Gebhardt ◽  
Hans-Willi Honegger
Keyword(s):  
Electrical Stimulation ◽  
Experimental Evidence ◽  
Nerve Cord ◽  
Ventral Nerve Cord ◽  
Sensory Nerves ◽  
Gryllus Bimaculatus ◽  
Central Origin ◽  
Gryllus Campestris ◽  
Descending Interneurons ◽  
Stimulation Of

SUMMARY We investigated five different descending brain interneurons with dendritic arborizations in the deutocerebrum in the crickets Gryllus bimaculatus and G. campestris. These interneurones convey specific antennal mechanosensory information to the ventral nerve cord and all responded to forced antennal movements. These interneurones coded for velocity and showed preferences for distinct sectors of the total range of antennal movements. Their axons descended into the posterior connective either ipsilateral or contalateral to the cell body. Electrical stimulation of sensory nerves indicated that the interneurons received input from different afferents of the two antennal base segments. One interneuron had a particularly large axon with a conduction velocity of 4.4ms−1. This was the only one of the five interneurons that also received visual input. Its activity was reduced during voluntary antennal movements. The reduction in activity occurred even after de-efferentation of the antenna, indicating that it had a central origin. Although we do not have experimental evidence for behavioural roles for the descending antennal mechanosensory interneurons, the properties described here suggest an involvement in the perception of objects in the path of the cricket.

Reflex Vocal Fold Adduction in the Porcine Model: The Effects of Stimuli Delivered to Various Sensory Nerves

2008 ◽  
Vol 117 (10) ◽  
pp. 749-752 ◽  
Author(s):  
Jeong-Soo Woo ◽  
Jagdeep S. Hundal ◽  
Clarence T. Sasaki ◽  
Mikhail W. Abdelmessih ◽  
Stephen P. Kelleher
Keyword(s):  
Vocal Fold ◽  
Porcine Model ◽  
Superior Laryngeal Nerve ◽  
Sensory Nerves ◽  
Internal Branch ◽  
Pharyngeal Plexus ◽  
Closing Force ◽  
Intercostal Nerves ◽  
Glottic Closure Reflex ◽  
Stimulation Of

Objectives: The aim of this study was to identify a panel of sensory nerves capable of eliciting an evoked glottic closure reflex (GCR) and to quantify the glottic closing force (GCF) of these responses in a porcine model. Methods: In 5 pigs, the internal branch of the superior laryngeal nerve (iSLN) and the trigeminal, pharyngeal plexus, glossopharyngeal, radial, and intercostal nerves were surgically isolated and electrically stimulated. During stimulation of each nerve, the GCR was detected by laryngeal electromyography and the GCF was measured with a pressure transducer. Results: The only nerve that elicited the GCR in the 5 pigs was the iSLN. The average GCF was 288.9 mm Hg. Conclusions: This study demonstrates that the only afferent nerve that elicits the GCR in pigs is the iSLN, and that it should remain the focus of research for the rehabilitation of patients with absent or defective reflex vocal fold adduction.

Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder

1995 ◽  
Vol 268 (2) ◽  
pp. H526-H534 ◽  
Author(s):  
H. L. Pan ◽  
A. C. Bonham ◽  
J. C. Longhurst
Keyword(s):  
Intrathecal Injection ◽  
Left Ventricular Pressure ◽  
Cardiovascular Responses ◽  
Pressure Change ◽  
Left Ventricular ◽  
Chemical Stimulation ◽  
Intrathecal Catheter ◽  
Nk1 Receptors ◽  
Stimulation Of

The present study examined the role of substance P (SP) as a sensory neurotransmitter in cardiovascular responses to bradykinin applied on the gallbladder. Experiments were performed in anesthetized cats in which sympathetic chains were transected at the T5-T6 level, and the tip of the intrathecal catheter was positioned at T6-T7 to limit the injectate between T6 and L2. Bradykinin (10 micrograms/ml) was applied onto the gallbladder before and after intrathecal injection of [D-Pro2,D-Phe7,D-Trp9]SP (100–200 micrograms, NK1/NK2-receptor antagonist), CP-99,994 (50–100 micrograms, selective NK1 antagonist), MEN-10,376 (100–500 micrograms, selective NK2 antagonist), or vehicle. Intrathecal injection of NK1 but not NK2 antagonist significantly reduced increases in mean arterial pressure, heart rate, and maximal rate of left ventricular pressure change by 28 +/- 2 mmHg (33 +/- 4%), 4 +/- 1 beats/min (42 +/- 5%), and 497 +/- 46 mmHg/s (36 +/- 4%), respectively. Intrathecal injection of NK1 or NK1/NK2 antagonist had no effect on cardiovascular responses evoked by electrical stimulation in the rostral ventral lateral medulla. These data suggest that endogenous SP, acting as a sensory neurotransmitter, is involved in the excitatory cardiovascular reflex caused by chemical stimulation of the gallbladder through its action on NK1 receptors in the spinal cord.

Effect of Various Sensory Stimuli on Reflex Laryngeal Adduction

1977 ◽  
Vol 86 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Masafumi Suzuki ◽  
Clarence T. Sasaki
Keyword(s):  
Splanchnic Nerve ◽  
Laryngeal Nerve ◽  
Organ System ◽  
Sensory Nerves ◽  
The Other ◽  
Evoked Responses ◽  
Sensory Stimuli ◽  
Adult Cats ◽  
Repetitive Electrical Stimulation ◽  
Stimulation Of

Various types of sensory stimuli may influence reflex laryngeal adduction. The recurrent laryngeal nerve responses evoked by single shock and repetitive electrical stimulation of a number of sensory nerves have been neurophysiologically observed in twenty-five adult cats. Stimulation of major cranial afferents produces strong adductor responses. The magnitude of these evoked responses is approached only by stimulation of the splanchnic nerve in the abdomen. On the other hand, comparable stimulation of special sensory and spinal somatic sensory nerves produces rapidly attenuated evoked adductor responses. We postulate that while these latter adductor responses may be insufficient to produce strong glottic closure, they may effectively modify phonatory function of the larynx. We have, therefore, attempted to demonstrate the effects of various sensory elicitations upon reflex laryngeal adduction as they may compositely influence both protective and phonatory control of this organ system.

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