A model for computer simulation of P-glycoprotein and transmembrane ΔpH-mediated anthracycline transport in multidrug-resistant tumor cells

1990 ◽  
Vol 1055 (2) ◽  
pp. 117-125 ◽  
Author(s):  
Erland J.F. Demant ◽  
Maxwell Sehested ◽  
Peter Buhl Jensen
Keyword(s):  
Computer Simulation ◽  
Tumor Cells ◽  
Multidrug Resistant ◽  
P Glycoprotein

scholarly journals Monoclonal Anti-P-glycoprotein Antibody-dependent Killing of Multidrug-resistant Tumor Cells by Human Mononuclear Cells

1990 ◽  
Vol 81 (11) ◽  
pp. 1155-1161 ◽  
Author(s):  
Yuji Heike ◽  
Hirofumi Hamada ◽  
Noriaki Inamura ◽  
Saburo Sone ◽  
Takeshi Ogura ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Mononuclear Cells ◽  
Multidrug Resistant ◽  
Human Mononuclear Cells ◽  
P Glycoprotein

Imaging of the P-glycoprotein in normal and multidrug-resistant small-cell lung carcinoma cells with the Atomic-Force Microscope(AFM)

1994 ◽  
Vol 52 ◽  
pp. 1074-1075
Author(s):  
J. M. Tsai ◽  
D. Sadava ◽  
S. A. C. Gould
Keyword(s):  
Tumor Cells ◽  
Small Cell Lung Carcinoma ◽  
Protein A ◽  
Multidrug Resistant ◽  
Extracellular Medium ◽  
Contact Mode ◽  
Cell Lung Carcinoma ◽  
Lung Carcinoma Cells ◽  
Atomic Force ◽  
P Glycoprotein

Cancer is characterized by the often rapid and uncontrolled rate of cell growth. This alteration in growth pattern causes normal cells to become tumor cells. After undergoing a period of chemotherapy, some tumor cells become resistant to a variety of drugs, a phenomenon known as the multidrug resistance (MDR). One explanation for this change is the overexpression of P-glycoprotein in the drug-resistant cells. This membrane protein is capable of pumping drugs into the extracellular medium. Since the drugs do not accumulate, the tumor cells are not killed. In order to examine this protein, a contact mode AFM was used to image the cell membranes of both the normal and the MDR tumor cells. The four figures provided show the topographical information of the membranes and suggest that there are differences between the cell lines.

The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells

2004 ◽  
Vol 28 (4) ◽  
pp. 283-293 ◽  
Author(s):  
Dorota Głowacka-Rogacka ◽  
Małgorzata Arciemiuk ◽  
Agnieszka Kupiec ◽  
Maria M. Bontemps-Gracz ◽  
Edward Borowski ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Multidrug Resistant ◽  
P Glycoprotein

scholarly journals Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein

2001 ◽  
Vol 94 (6) ◽  
pp. 864-872 ◽  
Author(s):  
Revital Niv ◽  
Yehuda G. Assaraf ◽  
Dina Segal ◽  
Esther Pirak ◽  
Yoram Reiter
Keyword(s):  
Tumor Cells ◽  
Multidrug Resistant ◽  
Single Chain ◽  
P Glycoprotein ◽  
Single Chain Fv ◽  
Single Chain Fv Fragment
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