Frontal lobe degeneration of non-Alzheimer type. III. Regional cerebral blood flow

Abstract Objective To identify regional cerebral blood flow (rCBF) differences between individuals who self-reported either low or high symptoms of somatic anxiety. Method Individuals who reported low levels of somatic anxiety (0-20th percentile;n = 8962,Mage = 39.2,39.2% female,62.6% Caucasian) and individuals who reported high levels of somatic anxiety (80-100th percentile;n = 6427,Mage = 40.9,39.0% female,69.5% Caucasian) were selected from a deidentified adult clinical outpatient database. Those with comorbid diagnoses were included. Significant differences (alpha = 0.001) were found for age [t(15387) = 6.3], and race [χ2(15) = 119.4] between groups and therefore were controlled. Results Significant rCBF differences were noted bilaterally in the frontal lobe [left: F(1,15,384) = 16.4; right: F(1,15,384) = 13.2] and motor-sensory strip [left: F(1,15,384) = 4.3; right: F(1,15,384) = 5.1]. Group means comparisons indicated higher perfusion in the frontal lobe of the high levels of somatic anxiety group. Lower perfusion was found in the motor sensory strip of the high levels of somatic anxiety group. No significant differences were found bilaterally in the cerebellum, limbic system, basal ganglia, vermis, or occipital, parietal, or temporal lobes. Conclusion Results indicated that individuals who report higher levels of somatic anxiety have higher perfusion in the frontal lobes and lower perfusion motor-sensory strip. Previous literature SPECT studies have found a link between individuals with panic disorder and increased activity in the right medial and superior frontal lobes. No research was found for anxiety in the motor-sensory strip. Limitations included the reliance on self-report measures of anxiety in place of clinical measures and the potential mediating effect of medication on somatic symptoms. Future research should examine perfusion in the motor-sensory strip, use clinical measures of anxiety, and control for mediation use.

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Comparative assessment of regional cerebral blood flow through combination therapy of iron with B4, C0Q10 for 2years in Alzheimer's disease and senile dementia of Alzheimer type

Neurobiology of Aging ◽

10.1016/0197-4580(92)90200-h ◽

1992 ◽

Vol 13 ◽

pp. S19

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Combination Therapy ◽

Regional Cerebral Blood Flow ◽

Senile Dementia ◽

Comparative Assessment ◽

Regional Cerebral Blood ◽

Alzheimer Type ◽

Dementia Of Alzheimer Type ◽

Flow Through

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Ictal regional cerebral blood flow in frontal lobe seizures

Seizure ◽

10.1016/s1059-1311(97)80039-8 ◽

1997 ◽

Vol 6 (5) ◽

pp. 393-401 ◽

Cited By ~ 13

Author(s):

Roderick Duncan ◽

James Patterson ◽

Donald Hadley ◽

Richard Roberts

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Frontal Lobe ◽

Regional Cerebral Blood Flow ◽

Regional Cerebral Blood ◽

Frontal Lobe Seizures

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L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1996.271.4.h1717 ◽

1996 ◽

Vol 271 (4) ◽

pp. H1717-H1719 ◽

Cited By ~ 7

Author(s):

J. Ma ◽

W. Meng ◽

C. Ayata ◽

P. L. Huang ◽

M. C. Fishman ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Mutant Mice ◽

Type I ◽

Wild Type ◽

Regional Cerebral Blood ◽

Doppler Flowmetry ◽

Type Iii ◽

Cranial Window

The effect of NG-nitro-L-arginine (L-NNA) on regional cerebral blood flow (rCBF) response to hypercapnia (5% CO2 inhalation) was studied in urethan-anesthetized wild-type (SV-129) and type III nitric oxide (NO) synthase (NOS)-deficient mice, using laser-Doppler flowmetry and the closed cranial window technique. Resting rCBF during normocapnia decreased by approximately 25% after L-NNA superfusion in wild-type mice only (n = 18), suggesting a role for type III NOS in baseline blood flow. Hypercapnia augmented rCBF approximately 50% in both wild-type and type III NOS mutant mice. L-NNA superfusion (1 mM) inhibited this increase by approximately 60% in both strains. Hence, synthesis of NO by the constitutively expressed type I NOS contributes to blood flow augmentation during hypercapnia.

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Effects of Immobilization Stress on Regional Cerebral Blood Flow in the Conscious Rat

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.1981.19 ◽

1981 ◽

Vol 1 (2) ◽

pp. 187-194 ◽

Cited By ~ 46

Author(s):

M. Ohata ◽

W. R. Fredericks ◽

U. Sundaram ◽

S. I. Rapoport

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Frontal Lobe ◽

Regional Cerebral Blood Flow ◽

Immobilization Stress ◽

Brain Regions ◽

Regional Cerebral Blood ◽

Conscious Rat ◽

Average Slope ◽

Wistar Kyoto

Immobilization stress of conscious, normotensive, freely breathing 10-month-old Wistar-Kyoto rats produced an overall decline in regional cerebral blood flow (rCBF), as measured with [14C]iodoantipyrine, except at the frontal lobe. In 14 brain regions, rCBF fell by an average of 14.3% after 5 min of immobilization and by 11.9% after 15 min. Immobilization stress also stimulated hyperventilation and thereby reduced Paco2. The slope relating rCBF to Paco2 averaged 1.5 ml 100 g−1 min−1 mm Hg−1 in 9 significantly affected regions. The findings suggest that rCBF declines during immobilization stress because of cerebrovascular constriction caused by a reduction in Paco2. Comparison of the average slope with published values indicates furthermore that were Paco2 to remain unchanged during immobilization, rCBF would increase by at most 20%.

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