In vivo characteristics of low molecular weight copoly(L-lactic acid/glycolic acid) formulations with controlled release of luteinizing hormone-releasing hormone agonist

1989 ◽  
Vol 9 (2) ◽  
pp. 111-122 ◽  
Author(s):  
Asano Masaharu ◽  
Fukuzaki Hironobu ◽  
Yoshida Masaru ◽  
Kumakura Minoru ◽  
Mashimo Tooru ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Controlled Release ◽  
Luteinizing Hormone ◽  
Glycolic Acid ◽  
Low Molecular Weight ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone

In vivo characteristics of low molecular weight copoly(D,L-lactic acid) formulations with controlled release of LH-RH agonist

Biomaterials ◽  
1989 ◽  
Vol 10 (8) ◽  
pp. 569-573 ◽  
Author(s):  
M ASANO ◽  
H FUKUZAKI ◽  
M YOSHIDA ◽  
M KUMAKURA ◽  
T MASHIMO ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Controlled Release ◽  
Low Molecular Weight ◽  
Lh Rh

In vivo Release of Dopamine, Luteinizing Hormone-Releasing Hormone and Thyrotropin-Releasing Hormone in Male Rats Bearing a Prolactin-Secreting Tumor

1987 ◽  
Vol 46 (2) ◽  
pp. 110-116 ◽  
Author(s):  
James L. Voogt ◽  
Wim J. de Greef ◽  
Theo J. Visser ◽  
Jurien de Koning ◽  
Jan T.M. Vreeburg ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Male Rats ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
In Vivo Release

INHIBITION BY MELATONIN OF THE PITUITARY RESPONSE TO LUTEINIZING HORMONE RELEASING HORMONE IN VIVO

1978 ◽  
Vol 76 (3) ◽  
pp. 487-491 ◽  
Author(s):  
K. YAMASHITA ◽  
M. MIENO ◽  
T. SHIMIZU ◽  
ER. YAMASHITA
Keyword(s):  
Luteinizing Hormone ◽  
Carotid Artery ◽  
Anterior Pituitary ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Lh Rh ◽  
Lh Secretion

The rate of secretion of 17-oxosteroids by the testes of anaesthetized dogs in vivo was used as an index of LH secretion. Intracarotid injection of luteinizing hormone releasing hormone (LH-RH, 1, 5 or 10 μg/kg body wt) resulted in an increase in the testicular 17-oxosteroid secretion which was roughly proportional to the dose administered and which reached a maximum 60 min after the injection. Testicular output of 17-oxosteroids was unaffected by administration of melatonin (10 or 100 μg/kg body wt) into the carotid artery. When LH-RH (5 μg/kg) was injected into the carotid artery 3 h after intracarotid injection of melatonin (10 or 100 μg/kg), the testicular response to LH-RH was considerably diminished. Pretreatment with melatonin (100 μg/kg) did not alter the testicular response to human chorionic gonadotrophin (20 i.u./kg body wt) given i.v. It is concluded that melatonin may act directly on the anterior pituitary gland in dogs to inhibit the LH-RH-induced release of LH.

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