Antiemetic efficacy of high-dose dexamethasone: randomized, double-blind, crossover study with high-dose metoclopramide in patients receiving cancer chemotherapy

1986 ◽  
Vol 22 (3) ◽  
pp. 283-288 ◽  
Author(s):  
Ezzeldin M. Ibrahim ◽  
Hassan Y. Al-Idrissi ◽  
Abdelwahab Ibrahim ◽  
Gamil Absood ◽  
Eman Al-Dossary ◽  
...  
Keyword(s):  
Crossover Study ◽  
Cancer Chemotherapy ◽  
High Dose ◽  
Double Blind ◽  
Antiemetic Efficacy ◽  
High Dose Dexamethasone ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide.

1984 ◽  
Vol 2 (5) ◽  
pp. 466-471 ◽  
Author(s):  
M S Aapro ◽  
P M Plezia ◽  
D S Alberts ◽  
V Graham ◽  
S E Jones ◽  
...  
Keyword(s):  
Side Effects ◽  
Crossover Study ◽  
Nausea And Vomiting ◽  
High Dose ◽  
Severe Nausea ◽  
Double Blind ◽  
Antiemetic Efficacy ◽  
High Dose Dexamethasone ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Nausea and vomiting remain common and debilitating side effects of therapy with many anticancer drugs. Recent reports have shown that both metoclopramide and dexamethasone are effective drugs for the treatment of severe nausea and vomiting caused by cis-platinum. A double-blind crossover study comparing the antiemetic properties of high-dose oral and intravenous regimens of metoclopramide and dexamethasone in outpatients was carried out. Standardized patient questionnaires and interviews were used to evaluate response. Dexamethasone and metoclopramide protected against more than five episodes of emesis in 48% and 40% of patients, respectively. Nausea persisted for less than six hours in 45% of patients on dexamethasone and in 37% on metoclopramide. The antiemetic efficacy of both regimens was retained through repeated courses of chemotherapy. Side effects were minimal with dexamethasone; however, 33% of patients experienced unacceptable extrapyramidal side effects to metoclopramide. Patient preference was significantly in favor of dexamethasone: 70% of patients chose to continue dexamethasone compared to 22% who preferred metoclopramide and 8% who chose other antiemetics. Dexamethasone was the preferred antiemetic in this patient population due to minimal side effects.

The Efficacy of High-Dose Olanzapine Versus Clozapine in Treatment-Resistant Schizophrenia: A Double-Blind Crossover Study

2003 ◽  
Vol 23 (6) ◽  
pp. 668-671 ◽  
Author(s):  
Robert R. Conley ◽  
Deanna L. Kelly ◽  
Charles M. Richardson ◽  
Carol A. Tamminga ◽  
William T. Carpenter
Keyword(s):  
Crossover Study ◽  
High Dose ◽  
Treatment Resistant ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Double-Blind Crossover Study of High-Dose Cetirizine in Cholinergic Urticaria

Dermatology ◽  
1996 ◽  
Vol 193 (4) ◽  
pp. 324-327 ◽  
Author(s):  
T. Zuberbier ◽  
C. Münzberger ◽  
U. Haustein ◽  
E. Trippas ◽  
B. Burtin ◽  
...  
Keyword(s):  
Crossover Study ◽  
High Dose ◽  
Double Blind ◽  
Cholinergic Urticaria ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Plasma concentrations of high-dose olanzapine in a double-blind crossover study

2006 ◽  
Vol 21 (6) ◽  
pp. 393-398 ◽  
Author(s):  
Deanna L. Kelly ◽  
Charles M. Richardson ◽  
Yang Yu ◽  
Robert R. Conley
Keyword(s):  
Crossover Study ◽  
Plasma Concentrations ◽  
High Dose ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Inhibition of Spontaneous Platelet Aggregation by Sulfinpyrazone

1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori
Keyword(s):  
Platelet Aggregation ◽  
Crossover Study ◽  
Double Blind ◽  
Platelet Aggregability ◽  
Initiation Of Therapy ◽  
Spontaneous Platelet Aggregation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.

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