Differences of draining lymph node cell proliferation among mice, rats and guinea pigs following exposure to metal allergens

Toxicology ◽  
1992 ◽  
Vol 76 (3) ◽  
pp. 283-292 ◽  
Author(s):  
Yoshiaki Ikarashi ◽  
Keiko Ohno ◽  
Toshie Tsuchiya ◽  
Akitada Nakamura
Keyword(s):  
Cell Proliferation ◽  
Lymph Node ◽  
Guinea Pigs ◽  
Lymph Node Cell ◽  
Draining Lymph Node

scholarly journals Regulation of lymph node vascular growth by dendritic cells

2006 ◽  
Vol 203 (8) ◽  
pp. 1903-1913 ◽  
Author(s):  
Brian Webster ◽  
Eric H. Ekland ◽  
Lucila M. Agle ◽  
Susan Chyou ◽  
Regina Ruggieri ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Proliferation ◽  
Endothelial Cells ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Cell Trafficking ◽  
Vascular Growth ◽  
Draining Lymph Node

Lymph nodes grow rapidly and robustly at the initiation of an immune response, and this growth is accompanied by growth of the blood vessels. Although the vessels are critical for supplying nutrients and for controlling cell trafficking, the regulation of lymph node vascular growth is not well understood. We show that lymph node endothelial cells begin to proliferate within 2 d of immunization and undergo a corresponding expansion in cell numbers. Endothelial cell proliferation is dependent on CD11c+ dendritic cells (DCs), and the subcutaneous injection of DCs is sufficient to trigger endothelial cell proliferation and growth. Lymph node endothelial cell proliferation is dependent on vascular endothelial growth factor (VEGF), and DCs are associated with increased lymph node VEGF levels. DC-induced endothelial cell proliferation and increased VEGF levels are mediated by DC-induced recruitment of blood-borne cells. Vascular growth in the draining lymph node includes the growth of high endothelial venule endothelial cells and is functionally associated with increased cell entry into the lymph node. Collectively, our results suggest a scenario whereby endothelial cell expansion in the draining lymph node is induced by DCs as part of a program that optimizes the microenvironment for the ensuing immune response.

Depression of Lymph Node Cell Proliferation Induced by Oxazolone

1987 ◽  
Vol 84 (3) ◽  
pp. 256-262 ◽  
Author(s):  
Ian Kimber ◽  
Belinda B. Pierce ◽  
Julie A. Mitchell ◽  
Avril Kinnaird
Keyword(s):  
Cell Proliferation ◽  
Lymph Node ◽  
Lymph Node Cell
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