Morphologic changes in the urinary bladder and stomach after long-term administration of sodium saccharin in F344 rats

1985 ◽  
Vol 29 (3) ◽  
pp. 255-263 ◽  
Author(s):  
Tsutomu Hibino ◽  
Yutaka Hirasawa ◽  
Masayuki Arai
Keyword(s):  
Urinary Bladder ◽  
Term Administration ◽  
Sodium Saccharin ◽  
F344 Rats ◽  
Morphologic Changes

Effect of Long-term Administration of Prostaglandin E1 on Morphologic Changes in Ductus Arteriosus

2020 ◽  
Vol 110 (6) ◽  
pp. 2088-2095
Author(s):  
Ryuma Iwaki ◽  
Hironori Matsuhisa ◽  
Susumu Minamisawa ◽  
Toru Akaike ◽  
Masato Hoshino ◽  
...  
Keyword(s):  
Prostaglandin E1 ◽  
Ductus Arteriosus ◽  
Term Administration ◽  
Morphologic Changes

The influence of doxazosin, an α1-adrenergic receptor antagonist on the urinary bladder contractility in pigs

2014 ◽  
Vol 17 (3) ◽  
pp. 527-529 ◽  
Author(s):  
W. Markiewicz ◽  
A. Jasiecka ◽  
D. Barski ◽  
J. Janiuk ◽  
A. Bossowska ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Adrenergic Receptor ◽  
Treated Group ◽  
Control Group ◽  
Detrusor Smooth Muscle ◽  
Before And After ◽  
Term Administration

Abstract In the present study influence of doxazosin on the porcine urinary bladder contractility has been examined. Immature pigs were treated for 30 days with: a) doxazosin (n = 5) per os at a dose of 0.1 mg/kg b.w. or b) placebo (n = 5; control group). Thereafter, animals were sacrificed and urinary bladder strips from the trigone were suspended in organ baths. The tension of the smooth musce was measured before and after exposition to acetylocholine (ACh; 10-5 - 10-3 M), norepinephrine (NE; 10-9 - 10-7 M) and 5-hydroxytryptamine (5-HT; 10-7 - 10-5 M). Both the ACh and 5-HT at the highest doses significantly increased the contractility in each group, but this response was weaker in doxazosin-treated animals. NE caused relaxation in both groups, but the effect was weaker in doxazosine-treated group. The results of our study have shown that long-term administration of doxazosin caused a desensitization of the detrusor smooth muscle for in vitro applied mediators of the autonomic nervous systems.

The effect of long-term administration of aspirin and sodium saccharin on the rat kidney

1986 ◽  
Vol 86 (1) ◽  
pp. 80-92 ◽  
Author(s):  
Sonny L. Johansson ◽  
Takao Sakata ◽  
Ryohei Hasegawa ◽  
Terry V. Zenser ◽  
Bernard B. Davis ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Term Administration ◽  
Sodium Saccharin

Membrane potentials of urinary bladder epithelium in F344 rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium saccharin

1983 ◽  
Vol 4 (6) ◽  
pp. 659-661 ◽  
Author(s):  
Katsumi Imaida ◽  
Masato Oshima ◽  
Shoji Fukushima ◽  
Nobuyuki Ito ◽  
Ken Hotta
Keyword(s):  
Urinary Bladder ◽  
Membrane Potentials ◽  
Bladder Epithelium ◽  
Sodium Saccharin ◽  
F344 Rats

The efficacy and safety of long-term administration of alpha-interferon and lamivudine in patients with chronic hepatitits B

2001 ◽  
Vol 120 (5) ◽  
pp. A572-A572
Author(s):  
F JABOLI ◽  
E RODA ◽  
C FABBRI ◽  
S MARCHETTO ◽  
F FERRARA ◽  
...  
Keyword(s):  
Alpha Interferon ◽  
Efficacy And Safety ◽  
Term Administration
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