An in vitro study of the effect of lipoxygenase and cyclo-oxygenase inhibitors of arachidonic acid on the induction and maintenance of long-term potentiation in the hippocampus

1989 ◽  
Vol 107 (1-3) ◽  
pp. 301-306 ◽  
Author(s):  
J.H. Williams ◽  
T.V.P. Bliss
Keyword(s):  
Arachidonic Acid ◽  
In Vitro Study ◽  
Long Term Potentiation ◽  
Vitro Study ◽  
Term Potentiation

Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type

2016 ◽  
Vol 27 (8) ◽  
pp. 849-855 ◽  
Author(s):  
Nickolay K. Isaev ◽  
Elena V. Stelmashook ◽  
Elisaveta E. Genrikhs ◽  
Galina A. Korshunova ◽  
Natalya V. Sumbatyan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Area ◽  
Hippocampal Slices ◽  
Amyloid Β ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Neuroprotective Action

AbstractIn 2008, using a model of compression brain ischemia, we presented the first evidence that mitochondria-targeted antioxidants of the SkQ family, i.e. SkQR1 [10-(6′-plastoquinonyl)decylrhodamine], have a neuroprotective action. It was shown that intraperitoneal injections of SkQR1 (0.5–1 μmol/kg) 1 day before ischemia significantly decreased the damaged brain area. Later, we studied in more detail the anti-ischemic action of this antioxidant in a model of experimental focal ischemia provoked by unilateral intravascular occlusion of the middle cerebral artery. The neuroprotective action of SkQ family compounds (SkQR1, SkQ1, SkQTR1, SkQT1) was manifested through the decrease in trauma-induced neurological deficit in animals and prevention of amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices. At present, most neurophysiologists suppose that long-term potentiation underlies cellular mechanisms of memory and learning. They consider inhibition of this process by amyloid-β1-42as anin vitromodel of memory disturbance in Alzheimer’s disease. Further development of the above studies revealed that mitochondria-targeted antioxidants could retard accumulation of hyperphosphorylated τ-protein, as well as amyloid-β1-42, and its precursor APP in the brain, which are involved in developing neurodegenerative processes in Alzheimer’s disease.

Effects of Cr(VI) long-term and low-dose action on mammalian antioxidant enzymes (an in vitro study)

2004 ◽  
Vol 98 (3) ◽  
pp. 490-496 ◽  
Author(s):  
Nino Asatiani ◽  
Nelly Sapojnikova ◽  
Marina Abuladze ◽  
Tamar Kartvelishvili ◽  
Nina Kulikova ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Low Dose ◽  
In Vitro Study ◽  
Vitro Study

Marginal, Internal Fit and Microleakage of Zirconia Infrastructures: An In-Vitro Study

2011 ◽  
Vol 36 (1) ◽  
pp. 72-79 ◽  
Author(s):  
L. Korkut ◽  
H. S. Cotert ◽  
H. Kurtulmus
Keyword(s):  
Clinical Relevance ◽  
In Vitro Study ◽  
Manufacturing Technology ◽  
Vitro Study ◽  
Internal Fit ◽  
Fitting Accuracy

Clinical Relevance Fitting accuracy and microleakage dominate prognostic covariates for the long-term durability of crown restorations. The fitting accuracy and microleakage potential of zirconia infrastructures might be influenced by manufacturing technology.

Enhancement of Hippocampal Long-Term Potentiation in Vitro by Fucosyl-Carbohydrates

1997 ◽  
pp. 905-908 ◽  
Author(s):  
H. Matthies ◽  
S. Staak ◽  
K. H. Smalla ◽  
M. Krug
Keyword(s):  
Long Term Potentiation ◽  
Term Potentiation
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