Protein kinase inhibitor attenuates apoptotic cell death induced by amyloid β protein in culture of the rat cerebral cortex

1996 ◽  
Vol 203 (3) ◽  
pp. 175-178 ◽  
Author(s):  
Keiichi Ueda ◽  
Tatsurou Yagami ◽  
Hiroyasu Kageyama ◽  
Kazuo Kawasaki
Keyword(s):  
Cell Death ◽  
Cerebral Cortex ◽  
Protein Kinase ◽  
Kinase Inhibitor ◽  
Apoptotic Cell ◽  
Amyloid Β ◽  
Protein Kinase Inhibitor ◽  
Rat Cerebral Cortex ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid β protein-induced neuronal cell death

2001 ◽  
Vol 134 (3) ◽  
pp. 673-681 ◽  
Author(s):  
Tatsurou Yagami ◽  
Keiichi Ueda ◽  
Kenji Asakura ◽  
Toshiyuki Sakaeda ◽  
Takayuki Kuroda ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Amyloid Β ◽  
Neuronal Cell ◽  
Amyloid Β Protein ◽  
Inflammatory Drug ◽  
Β Protein ◽  
Anti Inflammatory

Effects of endothelin B receptor agonists on amyloid β protein (25–35)-induced neuronal cell death

2002 ◽  
Vol 948 (1-2) ◽  
pp. 72-81 ◽  
Author(s):  
Tatsurou Yagami ◽  
Keiichi Ueda ◽  
Kenji Asakura ◽  
Takayuki Kuroda ◽  
Satoshi Hata ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Amyloid Β ◽  
Neuronal Cell ◽  
Amyloid Β Protein ◽  
Endothelin B Receptor ◽  
Receptor Agonists ◽  
Β Protein ◽  
Endothelin B

Microglial signaling by amyloid β protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS

Neuroreport ◽  
2001 ◽  
Vol 12 (11) ◽  
pp. 2567-2571 ◽  
Author(s):  
Hiroshi Hasegawa ◽  
Masamichi Nakai ◽  
Satoshi Tanimukai ◽  
Taizo Taniguchi ◽  
Akira Terashima ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Amyloid Β ◽  
Mitogen Activated Protein Kinase ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Mitogen Activated Protein

687 Differential patterns of amyloid β-protein deposition in cerebral cortex and leptomeninges

1996 ◽  
Vol 17 (4) ◽  
pp. S171
Author(s):  
Y. Shinkai ◽  
M. Yoshimura ◽  
Y. Ito ◽  
H. Shimada ◽  
A. Asami-Odaka ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Deposition ◽  
Β Protein

scholarly journals Negative Regulation of the Sapk/Jnk Signaling Pathway by Presenilin 1

2001 ◽  
Vol 153 (3) ◽  
pp. 457-464 ◽  
Author(s):  
Jin Woo Kim ◽  
Tong-Shin Chang ◽  
Ji Eun Lee ◽  
Sung-Ho Huh ◽  
Seung Woo Yeon ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Intracellular Signaling ◽  
Apoptotic Cell ◽  
Ectopic Expression ◽  
Amyloid Β ◽  
Mouse Embryonic Fibroblast ◽  
Mitogen Activated Protein Kinase ◽  
Presenilin 1 ◽  
Amyloid Β Protein ◽  
Jnk Pathway

Presenilin 1 (PS1) plays a pivotal role in Notch signaling and the intracellular metabolism of the amyloid β-protein. To understand intracellular signaling events downstream of PS1, we investigated in this study the action of PS1 on mitogen-activated protein kinase pathways. Overexpressed PS1 suppressed the stress-induced stimulation of stress-activated protein kinase (SAPK)/c-Jun NH2-terminal kinase (JNK) in human embryonic kidney 293 cells. Interestingly, two functionally inactive PS1 mutants, PS1(D257A) and PS1(D385A), failed to inhibit UV-stimulated SAPK/JNK. Furthermore, H2O2- or UV-stimulated SAPK activity was higher in mouse embryonic fibroblast (MEF) cells from PS1-null mice than in MEF cells from PS+/+ mice. MEFPS1(−/−) cells were more sensitive to the H2O2-induced apoptosis than MEFPS1(+/+) cells. Ectopic expression of PS1 in MEFPS1(−/−) cells suppressed H2O2-stimulated SAPK/JNK activity and apoptotic cell death. Together, our data suggest that PS1 inhibits the stress-activated signaling by suppressing the SAPK/JNK pathway.

scholarly journals The Cell Death-promoting Gene DP5, Which Interacts with the BCL2 Family, Is Induced during Neuronal Apoptosis Following Exposure to Amyloid β Protein

1999 ◽  
Vol 274 (12) ◽  
pp. 7975-7981 ◽  
Author(s):  
Kazunori Imaizumi ◽  
Takashi Morihara ◽  
Yasutake Mori ◽  
Taiichi Katayama ◽  
Manabu Tsuda ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Apoptosis ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Bcl2 Family ◽  
Β Protein
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