Changes in enzyme pattern of ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content

1975 ◽  
Vol 381 (2) ◽  
pp. 242-247 ◽  
Author(s):  
D.O. Schachtschabel ◽  
J. Yooktatat ◽  
C. Hirschhäuser
Keyword(s):  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Enzyme Pattern ◽  
Serial Cultivation

Increased Oxygen Consumption of Ehrlich Ascites Tumor Cells Following Serial Cultivation in Media with Increased (Hypertonic) NaCl Content

1972 ◽  
Vol 27 (7) ◽  
pp. 843-846 ◽  
Author(s):  
E. Kürschner ◽  
D. O. Schachtschabel
Keyword(s):  
Oxygen Consumption ◽  
Tumor Cells ◽  
High Salt ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Salt Tolerant ◽  
Ehrlich Ascites ◽  
Serial Cultivation ◽  
Cultivation In Vitro

Ehrlich ascites tumor cells adapted to serial cultivation in vitro in media with increased NaCl content (“high-salt”-tolerant cells) exhibit — in comparison with cells cultivated either in isotonic media or intraperitoneally in mice (in vivo) — an increased rate of cellular oxygen consumption. It is suggested that this increased respiratory rate of “high-salt”-tolerant cells reflects enhanced energy requirements associated with processes of active ion transport; and that the elevated environmental NaCl concentration may have “induced” a “step up” of the respiratory metabolism of these tumor cells.

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