Role of electron donor in propylene polymerization using magnesium chloride-supported titanium tetrachloride catalyst

Background: Reduced levels of magnesium can cause several diseases and increase cancer risk. Motivated by magnesium chloride’s (MgCl2) non-toxicity, physiological importance, and beneficial clinical applications, we studied its action mechanism and possible mechanical, molecular, and physiological effects in prostate cancer with different metastatic potentials.Methods: We examined the effects of MgCl2, after 24 and 48 hours, on apoptosis, cell migration, expression of epithelial mesenchymal transition (EMT) markers, and V-H+-ATPase, myosin II (NMII) and the transcription factor NF Kappa B (NFkB) expressions.Results: MgCl2 induces apoptosis, and significantly decreases migration speed in cancer cells with different metastatic potentials. MgCl2 reduces the expression of V-H+-ATPase and myosin II that facilitates invasion and metastasis, suppresses the expression of vimentin and increases expression of E-cadherin, suggesting a role of MgCl2 in reversing the EMT. MgCl2 also significantly increases the chromatin condensation and decreases NFkB expression.Conclusions: These results suggest a promising preventive and therapeutic role of MgCl2 for prostate cancer. Further studies should explore extending MgCl2 therapy to in vivo studies and other cancer types.Keywords: Magnesium chloride, prostate cancer, migration speed, V-H+-ATPase, and EMT.

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Preponderant role of pentafluorophenyl moieties for tuning the electronic properties of extended benzodifuran-azomethine derivatives

New Journal of Chemistry ◽

10.1039/d1nj01132d ◽

2021 ◽

Author(s):

Chady Moussallem ◽

Magali Allain ◽

Frédéric Gohier ◽

Pierre Frere

Keyword(s):

Electronic Properties ◽

Electron Donor ◽

Electron Acceptor

From a central 3,7-bis(perfluorophenyl)-BDF unit, the extension performed with electron acceptor perfluorophenyl groups and/or electron donor N,N-dimethylamino groups via an imine link leads to symmetrical AAA and DAD or dissymmetrical...

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Synthesis and properties of a new second-order NLO chromophore containing the benzo[b]furan moiety for electro-optical materials

RSC Advances ◽

10.1039/c4ra04466e ◽

2014 ◽

Vol 4 (63) ◽

pp. 33312-33318 ◽

Cited By ~ 11

Author(s):

Maolin Zhang ◽

Guowei Deng ◽

Airui Zhang ◽

Huajun Xu ◽

Heyan Huang ◽

...

Keyword(s):

Electron Donor ◽

Optical Materials ◽

Furan Ring ◽

Second Order ◽

Donor Group ◽

Nlo Chromophores ◽

Furan Moiety

We have designed and synthesized a new chromophore having a 1,1,7,7-tetramethyljulolidine fused furan ring as the electron donor group to systematically investigate the role of the benzo[b]furan ring in NLO chromophores.

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The role of bound potassium ions in the hydrolysis of low concentrations of adenosine triphosphate by preparations of membrane fragments from ox brain cerebral cortex

Biochemical Journal ◽

10.1042/bj1200015 ◽

1970 ◽

Vol 120 (1) ◽

pp. 15-24 ◽

Cited By ~ 18

Author(s):

P. S. G. Goldfarb ◽

R. Rodnight

Keyword(s):

Potassium Chloride ◽

Magnesium Chloride ◽

Adenosine Triphosphatase ◽

Time Course ◽

Atp Hydrolysis ◽

Protein Ratio ◽

Low Concentrations ◽

Hydrolysis Of ◽

Emission Flame

1. The intrinsic Na+, K+, Mg2+ and Ca2+ contents of a preparation of membrane fragments from ox brain were determined by emission flame photometry. 2. Centrifugal washing of the preparation with imidazole-buffered EDTA solutions decreased the bound Na+ from 90±20 to 24±12, the bound K+ from 27±3 to 7±2, the bound Mg2+ from 20±2 to 3±1 and the bound calcium from 8±1 to <1nmol/mg of protein. 3. The activities of the Na++K++Mg2+-stimulated adenosine triphosphatase and the Na+-dependent reaction forming bound phosphate were compared in the unwashed and washed preparations at an ATP concentration of 2.5μm (ATP/protein ratio 12.5pmol/μg). 4. The Na+-dependent hydrolysis of ATP as well as the plateau concentration of bound phosphate and the rate of dephosphorylation were decreased in the washed preparation. The time-course of formation and decline of bound phosphate was fully restored by the addition of 2.5μm-magnesium chloride and 2μm-potassium chloride. Addition of 2.5μm-magnesium chloride alone fully restored the plateau concentration of bound phosphate, but the rate of dephosphorylation was only slightly increased. Na+-dependent ATP hydrolysis was partly restored with 2.5μm-magnesium chloride; addition of K+ in the range 2–10μm-potassium chloride then further restored hydrolysis but not to the control rate. 5. Pretreatment of the washed preparation at 0°C with 0.5nmol of K+/mg of protein so that the final added K+ in the reaction mixture was 0.1μm restored the Na+-dependent hydrolysis of ATP and the time-course of the reaction forming bound phosphate. 6. The binding of [42K]potassium chloride by the washed membrane preparation was examined. Binding in a solution containing 10nmol of K+/mg of protein was linear over a period of 20min and was inhibited by Na+. Half-maximal inhibition of 42K+-binding required a 100-fold excess of sodium chloride. 7. It was concluded (a) that a significant fraction of the apparent Na+-dependent hydrolysis of ATP observed in the unwashed preparation is due to activation by bound K+ and Mg2+ of the Na++K++Mg2+-stimulated adenosine triphosphatase system and (b) that the enzyme system is able to bind K+ from a solution of 0.5μm-potassium chloride.

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Potential forMethanosarcinato contribute to uranium reduction during acetate-promoted groundwater bioremediation

10.1101/202242 ◽

2017 ◽

Author(s):

Dawn E Holmes ◽

Roberto Orelana ◽

Ludovic Giloteaux ◽

Li-Ying Wang ◽

Pravin Shrestha ◽

...

Keyword(s):

Field Experiment ◽

Electron Donor ◽

Enrichment Culture ◽

Cell Suspensions ◽

Contaminated Groundwater ◽

Subunit A ◽

Sedimentary Environments

AbstractPrevious studies ofin situbioremediation of uranium-contaminated groundwater with acetate injections have focused on the role ofGeobacterspecies in U(VI) reduction because of a lack of other abundant known U(VI)-reducing microorganisms. Monitoring the levels of methyl CoM reductase subunit A (mcrA) transcripts during an acetate-injection field experiment demonstrated that acetoclastic methanogens from the genusMethanosarcinawere enriched after 40 days of acetate amendment. The increased abundance ofMethanosarcinacorresponded with an accumulation of methane in the groundwater. An enrichment culture dominated by aMethanosarcinaspecies with the sameMethanosarcina mcrAsequence that predominated in the field experiment could effectively convert acetate to methane. In order to determine whetherMethanosarcinaspecies could be participating in U(VI) reduction in the subsurface, cell suspensions ofM. barkeriwere incubated in the presence of U(VI) with acetate provided as the electron donor. U(VI) was reduced by metabolically activeM. barkericells, however, no U(VI) reduction was observed in inactive controls. These results demonstrate thatMethanosarcinaspecies could play an important role in the long-term bioremediation of uranium-contaminated aquifers after depletion of Fe(III) oxides limits the growth ofGeobacterspecies. The results also suggest thatMethanosarcinahave the potential to influence uranium geochemistry in a diversity of anaerobic sedimentary environments.

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