Transitional cell carcinoma of the upper urinary tract is rare and presents quite interesting diagnostic and therapeutic problems. Available case studies, in accordance with literature on the subject, show how diagnosis relies on the combination of several data obtained from both traditional radiological methods and complementary tests. The importance of urography and retrograde ureteropyelography in providing morphological information is therefore fundamental and should be emphasised. It is advisable, however, to combine these data with those from urinary cytology, ultrasonography and to a lesser extent from CT scan, to be more sure of the nature and the extent of the disease.