Late onset of auditory deprivation does not affect brainstem auditory neuron soma size

1983 ◽  
Vol 12 (1) ◽  
pp. 145-147 ◽  
Author(s):  
Douglas B. Webster
Keyword(s):  
Late Onset ◽  
Auditory Neuron ◽  
Auditory Deprivation ◽  
Soma Size ◽  
Neuron Soma

scholarly journals Measurement of neuron soma size by fluorescent Nissl stain

2012 ◽  
Author(s):  
James Cronk ◽  
James Cronk ◽  
Noel Derecki ◽  
Jonathan Kipnis
Keyword(s):  
Soma Size ◽  
Nissl Stain ◽  
Neuron Soma

Mapping of neuron soma size as an effective approach to delineate differences between neural populations

2018 ◽  
Vol 304 ◽  
pp. 126-135 ◽  
Author(s):  
Alexander J. Lingley ◽  
Joshua C. Bowdridge ◽  
Reza Farivar ◽  
Kevin R. Duffy
Keyword(s):  
Neural Populations ◽  
Soma Size ◽  
Neuron Soma

scholarly journals Assessment of acceptable noise level in unilateral hearing aid users

2020 ◽  
Author(s):  
Kumars Akaberi ◽  
Hamid Jalilvand ◽  
Mohammad Ebrahim Mahdavi ◽  
Ahmadreza Nazeri1 ◽  
Seyed Mehdi Tabatabaee
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
Noise Level ◽  
Late Onset ◽  
Hearing Aid ◽  
Auditory Deprivation ◽  
Hearing Aid Fitting ◽  
Significant Difference ◽  
Acceptable Noise Level ◽  
The Mean

Background and Aim: It is well known that hearing aid fitting is an effective approach to improve the communication ability of hearingimpaired people. In the past, most of the hearing aids were fitted unilaterally rather than bilaterally. Whereas the unilateral hearing aid fitting improves verbal communication partially, it causes late-onset auditory deprivation. The main aim of this study is to investigate the ANL for each ear among the users with unilateral hearing aid experience. Methods: A total of 23 participants were recruited (14 females, 9 males). The mean age was 74.65 years (ranged from 41 to 83). All subjects had bilateral symmetric sensorineural hearing loss. The most comfortable level (MCL), Background Noise Level (BNL), and acceptable noise level (ANL) were measured for ear with amplification experience and ear without experience. Results: MCL, BNL and ANL in the aided ear was 82.22, 73.48 and 8.74 respectively, in addition in the unaided ear the results for MCL, BNL and ANL was 81.78, 72.13 and 9.65 respectively. Comparing the mean values of MCL, BNL and ANL between two ears showed no significant difference. Conclusion: There was not any difference for BNL and ANL measures Keywords: Bilateral hearing loss; acceptable noise level; late onset auditory deprivation; Hearing aid 

Late‐onset auditory deprivation: Effects of monaural versus binaural hearing aids

1984 ◽  
Vol 76 (5) ◽  
pp. 1357-1362 ◽  
Author(s):  
Shlomo Silman ◽  
Stanley A. Gelfand ◽  
Carol Ann Silverman
Keyword(s):  
Hearing Aids ◽  
Late Onset ◽  
Binaural Hearing ◽  
Auditory Deprivation ◽  
Binaural Hearing Aids

Case Studies in Neuroscience - Neuropathology and Diaphragm Dysfunction in Ventilatory Failure from Late-Onset Pompe Disease

2021 ◽  
Author(s):  
David Fuller ◽  
Jorge A Trejo-Lopez ◽  
Anthony T Yachnis ◽  
Michael D Sunshine ◽  
Sabhya Rana ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Respiratory Failure ◽  
Pompe Disease ◽  
Late Onset ◽  
Neuromuscular Disorder ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Soma Size ◽  
Ventilatory Failure ◽  
The Central Nervous System

Pompe disease (PD) is a neuromuscular disorder caused by a mutation in the acid alpha-glucosidase (GAA) gene. Late-onset PD patients retain some GAA activity and present symptoms later in life, with fatality mainly associated with respiratory failure. This case study presents diaphragm electrophysiology and a histological analysis of the brainstem, spinal cord, and diaphragm, from a male PD patient diagnosed with late-onset PD at age 35. The patient was wheelchair dependent by age 38, required nocturnal ventilation at age 40, 24-hour non-invasive ventilation by age 43, and passed away from respiratory failure at age 54. Diaphragm electromyography recorded using indwelling "pacing" wires showed asynchronous bursting between the left and right diaphragm during brief periods of independent breathing. The synchrony declined over a 4-year period preceding respiratory failure. Histological assessment indicated motoneuron atrophy in the medulla and rostral spinal cord. Hypoglossal (soma size: 421 ± 159 µm2) and cervical motoneurons (soma size: 487 ± 189 µm2) had an atrophied, elongated appearance. In contrast, lumbar (soma size: 1363 ± 677 µm2) and sacral motoneurons (soma size: 1411 ± 633 µm2) had the ballooned morphology typical of early-onset PD. Diaphragm histology indicated loss of myofibers. These results are consistent with neuromuscular degeneration and the concept that effective PD therapy will need to target the central nervous system, in addition to skeletal and cardiac muscle.

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