Guidelines for educating and long term treatment of non-insulin-dependent-diabetes-mellitus (NIDDM) patients developed by a quality circle of general practitioners — results after 2 years of study with 70 GPs

1994 ◽  
Vol 23 ◽  
pp. S73
Author(s):  
W. Sohn ◽  
J. Büchner ◽  
L. Kolodziej ◽  
R. Nöring ◽  
P. Helmich ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
General Practitioners ◽  
Insulin Dependent Diabetes Mellitus ◽  
Term Treatment ◽  
Dependent Diabetes Mellitus ◽  
Quality Circle ◽  
Long Term Treatment ◽  
Insulin Dependent ◽  
Niddm Patients

scholarly journals Role of ATP and Pi in the mechanism of insulin secretion in the mouse insulinoma βTC3 cell line

1997 ◽  
Vol 326 (3) ◽  
pp. 807-814 ◽  
Author(s):  
Klearchos K. PAPAS ◽  
Robert C. LONG ◽  
Ioannis CONSTANTINIDIS ◽  
Athanassios SAMBANIS
Keyword(s):  
Insulin Secretion ◽  
Glucose Concentration ◽  
Insulin Dependent Diabetes Mellitus ◽  
Term Treatment ◽  
Dependent Diabetes Mellitus ◽  
Bioartificial Pancreas ◽  
Long Term Treatment ◽  
Insulin Dependent ◽  
Glucose Stimulated Insulin Secretion

Understanding the biochemical events associated with glucose-stimulated insulin secretion by pancreatic β cells is of importance in gaining insight into both the pathophysiology of diabetes and the development of tissue-engineered bioartificial pancreatic substitutes. We have investigated the effects of glucose concentration on the bioenergetic status and on the metabolic and secretory functions exhibited by mouse insulinoma βTC3 cells entrapped in calcium alginate/poly-L-lysine/alginate (APA) beads. Cells entrapped in APA beads constitute a possible implantable bioartificial pancreas for the long-term treatment of insulin-dependent diabetes mellitus. Our results show that, in entrapped βTC3 cells, the oxygen consumption rate and the intracellular nucleotide triphosphate levels are unaffected by a step change in glucose concentration from 16 mM to 0 mM for 4.5 h and then back to 16 mM. The intracellular Pi level and the ammonia production rate were doubled, while insulin secretion was decreased 10-fold, upon switching from 16 mM to 0 mM glucose. The implications of these findings in the context of pancreatic β cell biochemistry and the mechanism of the ‘Fuel Hypothesis’ are discussed.

Long-term treatment of BAY g 5421 (acarbose) in noninsulin- dependent diabetes mellitus

1992 ◽  
pp. 251-257
Author(s):  
Yoshio Goto ◽  
T. Toyota ◽  
S. Oikawa ◽  
Y. Maruhama ◽  
M. Tamura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Term Treatment ◽  
Dependent Diabetes Mellitus ◽  
Long Term Treatment
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