Effects of winter nutrition and summer pasture or a feedlot diet on plasma Insulin-like Growth Factor I (IGF-I) and the relationship between circulating concentrations of IGF-I and thyroid hormones in steers

1990 ◽  
Vol 7 (4) ◽  
pp. 465-475 ◽  
Author(s):  
A.C. Hammond ◽  
T.H. Elsasser ◽  
W.E. Kunkle ◽  
T.S. Rumsey ◽  
M.J. Williams ◽  
...  
Keyword(s):  
Growth Factor ◽  
Thyroid Hormones ◽  
Plasma Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Summer Pasture ◽  
Growth Factor I ◽  
The Relationship

scholarly journals Origin of Plasma Insulin-Like Growth Factor-I (IGF-I) During Estrus in Goats

2003 ◽  
Vol 49 (3) ◽  
pp. 253-258 ◽  
Author(s):  
Sumie NONAKA ◽  
Tsutomu HASHIZUME ◽  
Mami HORIUCHI ◽  
Utako MIKAMI ◽  
Takeshi OSAWA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasma Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Hormonal control of insulin-like growth factor-I and growth hormone receptor mRNA expression by porcine hepatocytes in culture

1995 ◽  
Vol 146 (2) ◽  
pp. 239-245 ◽  
Author(s):  
J M Brameld ◽  
P A Weller ◽  
J C Saunders ◽  
P J Buttery ◽  
R S Gilmour
Keyword(s):  
Growth Factor ◽  
Thyroid Hormones ◽  
Mrna Expression ◽  
Culture Medium ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Class 1 ◽  
Growth Factor I ◽  
Porcine Hepatocytes

Abstract The effects of various hormones commonly added to hepatocyte culture media upon the expression of the GH receptor (GHR) and insulin-like growth factor-I (IGF-I) genes in cultured porcine hepatocytes were investigated. Preliminary investigations indicated that there was an absolute requirement only for insulin, with high losses of cell viability upon long term exclusion of insulin from the culture medium. The decline in GHR expression with time in culture was found to be less when high levels of glucose were included in the medium. Therefore the basal culture medium used in these studies was Williams' medium E supplemented with 0·2% (w/v) BSA, 5000 mg glucose/l and 100 nmol porcine insulin/l. The addition of dexamethasone (100 nmol/l) increased the expression of both GHR and IGF-I (class 1 transcripts only) mRNA (P<0·001 and P<0·05 respectively), and resulted in an increased responsiveness of IGF-I mRNA expression to GH (1 μg/ml), when the two were added in combination (although only class 1 transcripts were shown to be statistically significant, P<0·01). The addition of either thyroid hormone (1 nmol/l T3 or T4) alone also increased the expression of GHR mRNA (P<0·01) in addition to the dexamethasone stimulated expression, with T4 appearing to decrease IGF-I expression slightly (P<0·05) (either on its own or with T3). As with dexamethasone, the thyroid hormones increased the response of IGF-I mRNA expression to GH (1 μg/ml) when added in combination with GH (P<0·001). These observations demonstrate one possible mechanism for the interactions of glucocorticoids and thyroid hormones with the GH–IGF axis. Journal of Endocrinology (1995) 146, 239–245

Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs

1988 ◽  
Vol 118 (1) ◽  
pp. 105-108 ◽  
Author(s):  
J. Eugen Eigenmann ◽  
Adel Amador ◽  
Donald F. Patterson
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Growth Factor ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
The Mean ◽  
Growth Factor I

Abstract. Plasma insulin-like growth factor I concentrations from proportionate, chondrodystrophic and giant breeds were evaluated and compared with body size. IGF-I plasma concentrations were 91.2 ± 10.9 μg/l in Keeshounds (proportionate dog), 122.6 ± 25.4 μg/l in Bassethounds (chondrodystrophic dog) and 280 ± 22.8 μg/l in German Shepherds (proportionate dog). The highest IGF-I level (389.6 ± 24.2 μg/l) was found in the New Foundland, a giant breed (mean ± sem). The mean body weight was 11.8 ±0.4 kg in Keeshounds, 15.4 ± 1.4 kg in Bassethounds, 32 ± 1.5 kg in German Shepherds, and 45.6 ± 1.7 kg in New Foundlands (mean ± sem). Body weight and plasma IGF-I concentration were significantly correlated (y (IGF-I) = −7.43 + 8.7 × (body weight); P < 0.0001.

The influence of endocrine factors on the serum concentrations of insulin-like growth factor-I (IGF-I) and IGF-binding proteins

1993 ◽  
Vol 138 (3) ◽  
pp. 467-477 ◽  
Author(s):  
T. Sugisaki ◽  
T. Yamada ◽  
K. Takamatsu ◽  
T. Noguchi
Keyword(s):  
Growth Factor ◽  
Thyroid Hormones ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Igf Binding Proteins ◽  
Factor I ◽  
Igf I ◽  
Igf Binding ◽  
Growth Factor I ◽  
Igfbp 3

ABSTRACT Serum insulin-like growth factor-I (IGF-I) levels in lit (isolated GH deficiency), dw (panhypopituitarism), hyt (hypothyroidism) and cog (congenital goiter) mutant mice were found to be significantly lower than in control mice. In addition, liver and kidney IGF-I concentrations in mutants were also found to be significantly reduced compared with controls. These differences in IGF-I concentration were not observed in pg (genetic IGF receptor or post-receptor defect?) mice. These results indicated that serum IGF-I production is induced by thyroid hormones as well as by GH. Western blot analysis of serum IGF-binding protein (IGFBP) fractions revealed the following differences among the five mutants: the triplet of IGFBP-3 (42, 45 and 49 kDa) and IGFBP-4 (24 kDa) levels were significantly reduced. IGFBP-2 (32 kDa) levels were also reduced in the lit, hyt and cog mice, although the level in serum of dw mice was found to be greatly elevated. No differences in serum IGFBP levels were found in the pg mouse. Consequently, the ratio of IGFBP-3%: IGFBP-2% (the percentage of IGFBP-3 fraction of total IGFBP (IGFBP-3%) divided by that of IGFBP-2 (IGFBP-2%)) was decreased in GH-deficient mice but increased in hypothyroid mice, suggesting that IGFBP-3 and IGFBP-2 production in the liver is induced by GH and thyroid hormones respectively. Journal of Endocrinology (1993) 138, 467–477

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