NMDA receptor activation stimulates phospholipase A2 and somatostatin release from rat cortical neurons in primary cultures

1992 ◽  
Vol 225 (3) ◽  
pp. 253-262 ◽  
Author(s):  
Lucia Tapia-Arancibia ◽  
Florence Rage ◽  
Max Récasens ◽  
Jean-Philippe Pin
Keyword(s):  
Nmda Receptor ◽  
Phospholipase A2 ◽  
Cortical Neurons ◽  
Primary Cultures ◽  
Receptor Activation ◽  
Rat Cortical Neurons ◽  
Nmda Receptor Activation

scholarly journals Group IIA secretory phospholipase A2(GIIA) mediates apoptotic death during NMDA receptor activation in rat primary cortical neurons

2010 ◽  
Vol 112 (6) ◽  
pp. 1574-1583 ◽  
Author(s):  
Elena Chiricozzi ◽  
Seila Fernandez-Fernandez ◽  
Vincenza Nardicchi ◽  
Angeles Almeida ◽  
Juan Pedro Bolaños ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Phospholipase A2 ◽  
Cortical Neurons ◽  
Receptor Activation ◽  
Secretory Phospholipase A2 ◽  
Primary Cortical Neurons ◽  
Secretory Phospholipase ◽  
Apoptotic Death ◽  
Nmda Receptor Activation

scholarly journals NMDA Receptor Activation by Spontaneous Glutamatergic Neurotransmission

2009 ◽  
Vol 101 (5) ◽  
pp. 2290-2296 ◽  
Author(s):  
Felipe Espinosa ◽  
Ege T. Kavalali
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptors ◽  
Ampa Receptor ◽  
Cortical Neurons ◽  
Glutamate Release ◽  
Receptor Activation ◽  
Receptor Activity ◽  
Resting Membrane Potential ◽  
Nmda Current ◽  
Nmda Receptor Activation

Under physiological conditions N-methyl-d-aspartate (NMDA) receptor activation requires coincidence of presynaptic glutamate release and postsynaptic depolarization due to the voltage-dependent block of these receptors by extracellular Mg2+. Therefore spontaneous neurotransmission in the absence of action potential firing is not expected to lead to significant NMDA receptor activation. Here we tested this assumption in layer IV neurons in neocortex at their resting membrane potential (approximately −67 mV). In long-duration stable recordings, we averaged a large number of miniature excitatory postsynaptic currents (mEPSCs, >100) before or after application of dl-2 amino 5-phosphonovaleric acid, a specific blocker of NMDA receptors. The difference between the two mEPSC waveforms showed that the NMDA current component comprises ∼20% of the charge transfer during an average mEPSC detected at rest. Importantly, the contribution of the NMDA component was markedly enhanced at membrane potentials expected for the depolarized up states (approximately −50 mV) that cortical neurons show during slow oscillations in vivo. In addition, partial block of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor component of the mEPSCs did not cause a significant reduction in the NMDA component, indicating that potential AMPA receptor-driven local depolarizations did not drive NMDA receptor activity at rest. Collectively these results indicate that NMDA receptors significantly contribute to signaling at rest in the absence of dendritic depolarizations or concomitant AMPA receptor activity.

Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons

2005 ◽  
Vol 112 (10) ◽  
pp. 1297-1308 ◽  
Author(s):  
C. T. Mendes ◽  
W. F. Gattaz ◽  
E. L. Schaeffer ◽  
O. V. Forlenza
Keyword(s):  
Phospholipase A2 ◽  
Cortical Neurons ◽  
Primary Cultures ◽  
Rat Cortical Neurons ◽  
Phospholipase A2 Activity

NMDA receptor activation enhances diazepam binding inhibitor and its mRNA expressions in mouse cerebral cortical neurons

2001 ◽  
Vol 88 (1-2) ◽  
pp. 161-165 ◽  
Author(s):  
Masashi Katsura ◽  
Michihiko Takesue ◽  
Keijiro Shuto ◽  
Yutaka Mohri ◽  
Chihaya Tarumi ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Cortical Neurons ◽  
Receptor Activation ◽  
Cerebral Cortical Neurons ◽  
Nmda Receptor Activation

d-Serine regulates CREB phosphorylation induced by NMDA receptor activation in Müller glia from the retina

2007 ◽  
Vol 427 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Mónica Lamas ◽  
Irene Lee-Rivera ◽  
Mónica Ramírez ◽  
Ana María López-Colomé
Keyword(s):  
Nmda Receptor ◽  
Receptor Activation ◽  
Muller Glia ◽  
Müller Glia ◽  
Creb Phosphorylation ◽  
Nmda Receptor Activation
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