Development of an in vitro drug screening system for Mycobacterium leprae based on the determination of the intrabacterial sodium to potassium ratio of individual bacterial organisms

1994 ◽  
Vol 4 (4) ◽  
pp. 271-279 ◽  
Author(s):  
Monika Wiese ◽  
Buko Lindner ◽  
Ulrich Seydel
Keyword(s):  
Drug Screening ◽  
Mycobacterium Leprae ◽  
Screening System ◽  
In Vitro Drug Screening

In vitro drug screening system using membrane alteration in macrophages byMycobacterium leprae

1984 ◽  
Vol 6 (5) ◽  
pp. 709-716 ◽  
Author(s):  
M. V. Mankar ◽  
R. Jagannathan ◽  
P. R. Mahadevan
Keyword(s):  
Drug Screening ◽  
Screening System ◽  
In Vitro Drug Screening

Filter paper-based 3D liver model in vitro drug screening applications

2018 ◽  
Vol 44 ◽  
pp. S110
Author(s):  
T. Agarwal ◽  
T. Maiti ◽  
S. Ghosh
Keyword(s):  
Drug Screening ◽  
Filter Paper ◽  
Liver Model ◽  
In Vitro Drug Screening

Grafting of 3D Bioprinting to In Vitro Drug Screening: A Review

2020 ◽  
Vol 9 (7) ◽  
pp. 1901773 ◽  
Author(s):  
Jing Nie ◽  
Qing Gao ◽  
Jianzhong Fu ◽  
Yong He
Keyword(s):  
Drug Screening ◽  
3D Bioprinting ◽  
In Vitro Drug Screening

scholarly journals From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
Ming Wai Hung ◽  
Zai Jun Zhang ◽  
Shang Li ◽  
Benson Lei ◽  
Shuai Yuan ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Drug Screening ◽  
Environmental Science ◽  
Pharmacological Action ◽  
Zebrafish Model ◽  
Lead Compounds ◽  
Efficacy Parameters

The zebrafish (Danio rerio) has recently become a common model in the fields of genetics, environmental science, toxicology, and especially drug screening. Zebrafish has emerged as a biomedically relevant model forin vivohigh content drug screening and the simultaneous determination of multiple efficacy parameters, including behaviour, selectivity, and toxicity in the content of the whole organism. A zebrafish behavioural assay has been demonstrated as a novel, rapid, and high-throughput approach to the discovery of neuroactive, psychoactive, and memory-modulating compounds. Recent studies found a functional similarity of drug metabolism systems in zebrafish and mammals, providing a clue with why some compounds are active in zebrafishin vivobut notin vitro, as well as providing grounds for the rationales supporting the use of a zebrafish screen to identify prodrugs. Here, we discuss the advantages of the zebrafish model for evaluating drug metabolism and the mode of pharmacological action with the emerging omics approaches. Why this model is suitable for identifying lead compounds from natural products for therapy of disorders with multifactorial etiopathogenesis and imbalance of angiogenesis, such as Parkinson's disease, epilepsy, cardiotoxicity, cerebral hemorrhage, dyslipidemia, and hyperlipidemia, is addressed.

scholarly journals Microfluidics-assisted in vitro drug screening and carrier production

2013 ◽  
Vol 65 (11-12) ◽  
pp. 1575-1588 ◽  
Author(s):  
Jonathan H. Tsui ◽  
Woohyuk Lee ◽  
Suzie H. Pun ◽  
Jungkyu Kim ◽  
Deok-Ho Kim
Keyword(s):  
Drug Screening ◽  
In Vitro Drug Screening
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