Standardized varimax descriptors of event related potentials: Evaluation of psychiatric patients

1994 ◽  
Vol 55 (1) ◽  
pp. 13-40 ◽  
Author(s):  
E.Roy John ◽  
Leslie S. Prichep ◽  
Paul Easton
Keyword(s):  
Psychiatric Patients ◽  
Event Related Potentials ◽  
Related Potentials

Responses to External Emotions or their Transitions at Central to Peripheral Nervous System Levels: A Methodological Contribution to Mental Health

2020 ◽  
Vol 16 (2) ◽  
pp. 138-152
Author(s):  
Bingren Zhang ◽  
Chu Wang ◽  
Chanchan Shen ◽  
Wei Wang
Keyword(s):  
Healthy Volunteers ◽  
Psychiatric Patients ◽  
Event Related Potentials ◽  
Emotional Stimuli ◽  
Non Invasive ◽  
Related Potentials ◽  
Different Populations ◽  
Invasive Techniques ◽  
Psychiatric Problems ◽  
Different Levels

Background: Responses to external emotional-stimuli or their transitions might help to elucidate the scientific background and assist the clinical management of psychiatric problems, but pure emotional-materials and their utilization at different levels of neurophysiological processing are few. Objective: We aimed to describe the responses at central and peripheral levels in healthy volunteers and psychiatric patients when facing external emotions and their transitions. Methods: Using pictures and sounds with pure emotions of Disgust, Erotica, Fear, Happiness, Neutral, and Sadness or their transitions as stimuli, we have developed a series of non-invasive techniques, i.e., the event-related potentials, functional magnetic resonance imaging, excitatory and inhibitory brainstem reflexes, and polygraph, to assess different levels of neurophysiological responses in different populations. Results: Sample outcomes on various conditions were specific and distinguishable at cortical to peripheral levels in bipolar I and II disorder patients compared to healthy volunteers. Conclusions: Methodologically, designs with these pure emotions and their transitions are applicable, and results per se are specifically interpretable in patients with emotion-related problems.

scholarly journals Event Related Potentials and its role as Endophenotypes in Psychiatry

2014 ◽  
pp. 11-19
Author(s):  
Roshan Khanande ◽  
Bhoomika Sachacher ◽  
B Das ◽  
S H Nizamie
Keyword(s):  
Psychiatric Disorders ◽  
Cognitive Processes ◽  
Mismatch Negativity ◽  
Psychiatric Patients ◽  
Genetic Research ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Related Potentials ◽  
Bipolar Affective Disorders

Familial segregation is a norm rather than an exception in psychiatry. Genetic research has failed to provide much anticipated unanimous, if not awaited answers to the complex predispositions to psychiatric disorders. Hence, the concept of endophenotype took birth. Endophenotype is an attribute which is hidden phenotype, which is described as internal phenotypes discoverable by biochemical test or microscopic examination. This concept was immediately picked up by psychiatry, giving a totally new direction to the search for root cause of various psychiatric disorders.Cognitive deterioration is inseparable from psychiatric disorders, known since dawn of psychiatry. However, cognitive deficits in FDRs (First Degree Relatives) of psychiatric patients were one of the first endophenotypes noted. Event Related Potential (ERP), a science known to be electrophysiological counterpart of various cognitive processes, was soon incorporated in search of endophenotypes in psychiatry. In schizophrenia reduced amplitude of MMN(Mismatch negativity), impaired suppression of P50 and reduced amplitude of P300; reduced P300 amplitude, impaired P50 suppression in Bipolar Affective Disorders; reduced P300 amplitude in substance dependence disorders have been reported to have endophenotypic values. Various other ERP waves such as CNV, N400 have been investigated but no conclusive reports are out yet. The ultimate goal of this science is to search for genes governing the cognitive processes responsible for ERP waves identified as Endophenotypes for specific psychiatric disorders, and the search has just started.Keywords : Event Related Potential, Endophenotype, Psychiatric Disorder, Mismatch negativity,P 300, P 50, CNV

Utility of ERP measures in clinical research

1990 ◽  
Vol 2 (2) ◽  
pp. 30-37
Author(s):  
A. Kok
Keyword(s):  
Clinical Research ◽  
Psychiatric Patients ◽  
Event Related Potentials ◽  
Diagnostic Markers ◽  
Mental Processes ◽  
Theoretical Understanding ◽  
Psychophysiological Measures ◽  
Related Potentials ◽  
Attention Memory

SummaryPsychophysiological measures, such as late components of the event-related potentials (ERP's) may be applied in clinical nosological research in two different ways; as purely empirical or diagnostic markers and as markers of functional processes. The second application implies that ERP's may be used to increase the theoretical understanding of specific mental processes such as attention, memory and linguistic processes and the degree of impairment of these processes in psychiatric patients. Some examples derived from recent studies of dementia and aging are given of these two applications of ERP's.

Sign in / Sign up

Export Citation Format

Share Document