1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells

1996 ◽  
Vol 58 (4) ◽  
pp. 367-376 ◽  
Author(s):  
Maura Simboli-Campbell ◽  
Carmen J. Narvaez ◽  
Martin Tenniswood ◽  
JoEllen Welsh
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Biochemical Markers ◽  
Breast Cancer Cells ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Mcf 7

Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells

1994 ◽  
Vol 29 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Trudy Vink-van Wijngaarden ◽  
Huibert A. P. Pols ◽  
Cok J. Buurman ◽  
Jan C. Birkenhäger ◽  
Johannes P. T. M. van Leeuwen
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Combined Effects ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Mcf 7

scholarly journals Identification and characterization of a response element in the EGFR promoter that mediates transcriptional repression by 1,25-dihydroxyvitamin D3 in breast cancer cells

2005 ◽  
Vol 35 (1) ◽  
pp. 117-133 ◽  
Author(s):  
Kenneth R McGaffin ◽  
Susan A Chrysogelos
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mutational Analysis ◽  
Present Report ◽  
Heterologous Promoter ◽  
Response Element ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

Reduction of epidermal growth factor receptor (EGFR) mRNA and protein by 1,25-dihydroxyvitamin D3 has been documented in MCF7, T47D, and BT549 breast cancer cells. In the present report, functional mapping of the EGFR promoter in BT549 cells has revealed a sequence of DNA between nucleotide positions −536 and −478 that resembles a consensus vitamin D response element (VDRE) and confers a vitamin D response upon both the homologous and a minimal heterologous promoter. In vitro footprinting and gel shift assays demonstrate the presence of an unidentified nuclear factor that is required for strong binding of the vitamin D receptor (VDR) to this putative VDRE. An Sp1 binding site was also identified in close proximity and shown to bind Sp1 from nuclear extract. Mutational analysis and functional studies using a minimal heterologous promoter provide evidence that the VDR in concert with an unknown nuclear partner mediates basal EGFR repression through displacement of Sp1 which is augmented in the presence of a ligand.

1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects

2001 ◽  
Vol 67 (2) ◽  
pp. 157-168 ◽  
Author(s):  
Qin Wang ◽  
Dawn Lee ◽  
Vilayvanh Sysounthone ◽  
Roshantha A.S. Chandraratna ◽  
Sylvia Christakos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Additive Effects ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3
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