1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects

2001 ◽  
Vol 67 (2) ◽  
pp. 157-168 ◽  
Author(s):  
Qin Wang ◽  
Dawn Lee ◽  
Vilayvanh Sysounthone ◽  
Roshantha A.S. Chandraratna ◽  
Sylvia Christakos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Additive Effects ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

scholarly journals Identification and characterization of a response element in the EGFR promoter that mediates transcriptional repression by 1,25-dihydroxyvitamin D3 in breast cancer cells

2005 ◽  
Vol 35 (1) ◽  
pp. 117-133 ◽  
Author(s):  
Kenneth R McGaffin ◽  
Susan A Chrysogelos
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mutational Analysis ◽  
Present Report ◽  
Heterologous Promoter ◽  
Response Element ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

Reduction of epidermal growth factor receptor (EGFR) mRNA and protein by 1,25-dihydroxyvitamin D3 has been documented in MCF7, T47D, and BT549 breast cancer cells. In the present report, functional mapping of the EGFR promoter in BT549 cells has revealed a sequence of DNA between nucleotide positions −536 and −478 that resembles a consensus vitamin D response element (VDRE) and confers a vitamin D response upon both the homologous and a minimal heterologous promoter. In vitro footprinting and gel shift assays demonstrate the presence of an unidentified nuclear factor that is required for strong binding of the vitamin D receptor (VDR) to this putative VDRE. An Sp1 binding site was also identified in close proximity and shown to bind Sp1 from nuclear extract. Mutational analysis and functional studies using a minimal heterologous promoter provide evidence that the VDR in concert with an unknown nuclear partner mediates basal EGFR repression through displacement of Sp1 which is augmented in the presence of a ligand.

Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells

1994 ◽  
Vol 29 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Trudy Vink-van Wijngaarden ◽  
Huibert A. P. Pols ◽  
Cok J. Buurman ◽  
Jan C. Birkenhäger ◽  
Johannes P. T. M. van Leeuwen
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Combined Effects ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Mcf 7

Regulation of apoptosis in adipocytes and breast cancer cells by 1,25-dihydroxyvitamin D3: a link between obesity and breast cancer

2013 ◽  
Vol 14 (3) ◽  
Author(s):  
Igor N. Sergeev
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mammary Cancer ◽  
Tissue Mass ◽  
Dihydroxyvitamin D3 ◽  
Dihydroxyvitamin D ◽  
Promising Strategy ◽  
Adipose Tissue Mass

AbstractModulation of apoptosis is emerging as a promising strategy for prevention and treatment of breast cancer and obesity because removal of mammary cancer cells and mature adipocytes through this process will result in decreasing tumor size and produce long-term reduction in adipose tissue mass. The hormone 1,25-dihydroxyvitamin D

Effects of 1,25-dihydroxyvitamin D3 on cell-cycle kinetics of T 47D human breast cancer cells

1989 ◽  
Vol 138 (3) ◽  
pp. 611-616 ◽  
Author(s):  
John A. Eisman ◽  
Robert L. Sutherland ◽  
M. Lynne McMenemy ◽  
Jean-Charles Fragonas ◽  
Elizabeth A. Musgrove ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cell Cycle Kinetics ◽  
Dihydroxyvitamin D3 ◽  
Kinetics Of
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