Cerebral kinetics of the dopamine D2 receptor ligand [123I]IBZM in mice

2008 ◽  
Vol 35 (4) ◽  
pp. 467-473 ◽  
Author(s):  
Philipp T. Meyer ◽  
Dagmar Salber ◽  
Johannes Schiefer ◽  
Markus Cremer ◽  
Wolfgang M. Schaefer ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligand ◽  
Dopamine D2 ◽  
Kinetics Of

A Double-Injection Technique for in vivo Measurement of Dopamine D2-Receptor Density in Monkeys with 3-(2'-[18F] Fluoroethyl)Spiperone and Dynamic Positron Emission Tomography

1989 ◽  
Vol 9 (6) ◽  
pp. 850-858 ◽  
Author(s):  
Sung-Cheng Huang ◽  
Mark M. Bahn ◽  
Jorge R. Barrio ◽  
John M. Hoffman ◽  
Nagichettiar Satyamurthy ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Emission Tomography ◽  
Injection Technique ◽  
Receptor Density ◽  
Dopamine D2 ◽  
Positron Emission ◽  
Kinetics Of

Dopamine D2-receptor density in striatum of monkey was measured with 3-(2'-[18F]fluoroethyl)spiperone (FESP) and dynamic positron emission tomography (PET), using a double-injection technique. A first bolus of high specific activity (SA) FESP (5 mCi; ≃ 1 Ci/μmol) was injected i.v.; 90 min later, a second bolus of lower SA FESP (5 mCi; ≃ 0.04 Ci/μmol) was injected. A dynamic PET study was performed to measure the kinetics of FESP in striatum over 180 min, and the metabolite-corrected concentration of FESP in plasma as a function of time was obtained from arterial blood samples. A nonlinear compartmental model that took into account the saturability of the receptor binding was used to describe the kinetics of FESP in striatum. Model parameters were estimated by regression with a constraint based on information about the equilibrium dissociation constant of the ligand–receptor binding. Dopamine D2-receptor density in striatum was estimated to be 25.9 ± 12.7 pmol/g in seven Macaca nemestrina monkeys. The method does not require the use of cerebellum as a reference tissue region and an estimate of dopamine D2-receptor density can be obtained from a single study.

SSR181507, a dopamine D2 receptor and 5-HT1A receptor ligand: Evidence for mixed anxiolytic- and antidepressant-like activities

2011 ◽  
Vol 97 (3) ◽  
pp. 428-435 ◽  
Author(s):  
Denis Boulay ◽  
Ronan Depoortere ◽  
Caroline Louis ◽  
Martine Lacave ◽  
Marie Thérèse Lucas ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligand ◽  
Dopamine D2

Preparation and preliminary biological evaluation of [18F]NCQ-115: a new selective reversible dopamine D2 receptor ligand

1993 ◽  
Vol 20 (4) ◽  
pp. 549-555 ◽  
Author(s):  
A. Najafi ◽  
A. Peterson ◽  
M. Buchsbaum ◽  
S. O'Dell ◽  
F. Weihmuller
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Biological Evaluation ◽  
Receptor Ligand ◽  
Dopamine D2

The dopamine D2 receptor ligand 18F-desmethoxyfallypride: an appropriate fluorinated PET tracer for the differential diagnosis of parkinsonism

2004 ◽  
Vol 31 (8) ◽  
Author(s):  
Mathias Schreckenberger ◽  
Stefan H�gele ◽  
Thomas Siessmeier ◽  
Hans-Georg Buchholz ◽  
Heike Armbrust-Henrich ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligand ◽  
Dopamine D2 ◽  
Pet Tracer

Effects of acute and repeated treatment with a novel dopamine D2 receptor ligand on l-DOPA-induced dyskinesias in MPTP monkeys

2001 ◽  
Vol 412 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Abdallah Hadj Tahar ◽  
Anna Ekesbo ◽  
Laurent Grégoire ◽  
Evelyne Bangassoro ◽  
Kjell A Svensson ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Repeated Treatment ◽  
Receptor Ligand ◽  
Dopamine D2

scholarly journals Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141637 ◽  
Author(s):  
Sean M. Peterson ◽  
Thomas F. Pack ◽  
Marc G. Caron
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Functional Selectivity ◽  
Receptor Ligand ◽  
Dopamine D2
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