Methemoglobin levels during prolonged combined nitroglycerin and sodium nitroprusside infusions in infants after cardiac surgery

1994 ◽  
Vol 8 (6) ◽  
pp. 658-662 ◽  
Author(s):  
R.S. Williams ◽  
John J. Mickell ◽  
Edwin S. Young ◽  
Jay H. Shapiro ◽  
Gary K. Lofland
Keyword(s):  
Cardiac Surgery ◽  
Sodium Nitroprusside

The ECLIPSE Trials: Comparative Studies of Clevidipine to Nitroglycerin, Sodium Nitroprusside, and Nicardipine for Acute Hypertension Treatment in Cardiac Surgery Patients

2008 ◽  
Vol 107 (4) ◽  
pp. 1110-1121 ◽  
Author(s):  
Solomon Aronson ◽  
Cornelius M. Dyke ◽  
Kevin A. Stierer ◽  
Jerrold H. Levy ◽  
Albert T. Cheung ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Sodium Nitroprusside ◽  
Comparative Studies ◽  
Hypertension Treatment ◽  
Acute Hypertension

A Comparison of the Hemodynamic Effects of Amrinone and Sodium Nitroprusside in Infants After Cardiac Surgery

1997 ◽  
Vol 84 (2) ◽  
pp. 294-298 ◽  
Author(s):  
James M. Bailey ◽  
Bruce E. Miller ◽  
Kirk R. Kanter ◽  
Steven R. Tosone ◽  
Vincent K. H. Tam
Keyword(s):  
Cardiac Surgery ◽  
Sodium Nitroprusside ◽  
Hemodynamic Effects

A1053 COMPARISON OF PHENOXYBENZAMINE TO SODIUM NITROPRUSSIDE IN PEDIATRIC CARDIAC SURGERY

1997 ◽  
Vol 87 (Supplement) ◽  
pp. 1053A ◽  
Author(s):  
Emad Mossad ◽  
Maria Zestos ◽  
Roger Mee ◽  
Marvin Leventhal ◽  
Norman Starr
Keyword(s):  
Cardiac Surgery ◽  
Sodium Nitroprusside ◽  
Pediatric Cardiac Surgery

scholarly journals A Closed Loop Microprocessor Controller for Treatment of Hypertension after Cardiac Surgery

1986 ◽  
Vol 14 (2) ◽  
pp. 158-162 ◽  
Author(s):  
F. L. Rosenfeldt ◽  
V. Chang ◽  
M. Grigg ◽  
S. Parker ◽  
R. Cearns ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Surgery ◽  
Sodium Nitroprusside ◽  
Blood Pressure Response ◽  
Recovery Period ◽  
Pressure Response ◽  
Drug Infusion ◽  
Early Recovery ◽  
Hypotensive Drug ◽  
Safety Features

Hypertension after cardiac surgery is common and requires accurate control by carefully regulated infusions of drugs such as sodium nitroprusside. A microprocessor-based controller has been designed to close the loop between the blood pressure response and the infusion rate of a hypotensive drug. This system has been refined by computer simulation of the blood pressure response to sodium nitroprusside and by experience gained in using the controller in eleven patients in the early recovery period after cardiac surgery. The controller was able automatically to maintain blood pressure within 10% of a specified value. Provision of sophisticated safety features in automatic drug infusion controllers is essential for patient protection.

Nitroglycerin and Sodium Nitroprusside: Potential Contributors to Postoperative Bleeding?

2012 ◽  
Vol 15 (2) ◽  
pp. 92 ◽  
Author(s):  
Donald Clark ◽  
Stephanie Tesseneer ◽  
Curtis G. Tribble
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Sodium Nitroprusside ◽  
Platelet Activation ◽  
Postoperative Bleeding ◽  
Antihypertensive Agents ◽  
Platelet Inhibition ◽  
Clinical Consequence ◽  
Platelet Dysfunction ◽  
Knowing That

Postoperative bleeding is common in patients undergoing cardiac surgery with cardiopulmonary bypass. Most cases of severe postoperative bleeding not due to incomplete surgical hemostasis are related to acquired transient platelet dysfunction mediated by platelet activation during contact with the synthetic surfaces of the cardiopulmonary bypass equipment. Antihypertensive agents nitroglycerin and sodium nitroprusside have been shown to have platelet inhibitory properties, yet the clinical consequence in terms of postoperative bleeding has been little studied. Knowing that cardiopulmonary bypass causes platelet dysfunction, it is prudent for physicians to be aware of the additional platelet inhibition caused by these commonly used antihypertensive agents.

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