FIRST PASS ELIMINATION KINETICS OF DEXTROPROPOXYPHENE IN MAN

Abstracts ◽  
1978 ◽  
pp. 939
Author(s):  
J. Schou ◽  
L. Gram ◽  
W.L. Way ◽  
B. Gustavsson ◽  
N.-O. Bodin ◽  
...  
Keyword(s):  
Elimination Kinetics ◽  
First Pass ◽  
Kinetics Of

Clinical Pharmacokinetics of Chlorpheniramine

1984 ◽  
Vol 18 (9) ◽  
pp. 701-707 ◽  
Author(s):  
Martha M. Rumore
Keyword(s):  
Half Life ◽  
The Body ◽  
Pharmacokinetic Parameters ◽  
Pharmacokinetic Studies ◽  
Elimination Kinetics ◽  
Clinical Pharmacokinetics ◽  
Interindividual Variations ◽  
First Pass ◽  
Dose Levels ◽  
Kinetics Of

The clinical pharmacokinetics of chlorpheniramine are reviewed. Recent studies have established that the half-life of chlorpheniramine is longer than previously reported. Chlorpheniramine has a serum half-life of ∼20 hours in adults, and elimination from the body is primarily by metabolism to monodesmethyl and didesmethyl compounds. The half-life is increased in the presence of renal dysfunction and decreased in children. The exact mechanism of the presystemic first-pass elimination and the effects of dose levels on the process presently are unclear. Biopharmaceutical and pharmacokinetic studies after single or multiple doses in humans reveal wide interindividual variations in pharmacokinetics. Age, dialysis, urinary pH and flow influence the elimination kinetics of chlorpheniramine. Attention is brought to major issues that need further clarification to optimize drug therapy with this antihistamine. The use of pharmacokinetic parameters of chlorpheniramine for clinical application is discussed.

Theoretical study of the mechanisms for the homogenous gas-phase elimination kinetics of some 2-hydroxynitroalkanes

2006 ◽  
Vol 19 (12) ◽  
pp. 836-840 ◽  
Author(s):  
Rafael Añez ◽  
Rodolfo Izquierdo ◽  
Alba Vidal ◽  
Tania Cordova ◽  
Aníbal Sierraalta ◽  
...  
Keyword(s):  
Gas Phase ◽  
Theoretical Study ◽  
Elimination Kinetics ◽  
Kinetics Of ◽  
Phase Elimination

scholarly journals Regional distribution and elimination kinetics of imipramine in rat brain after multiple dosages.

1986 ◽  
Vol 34 (2) ◽  
pp. 927-930 ◽  
Author(s):  
Mikio Masada ◽  
Kazutoshi Suzuki ◽  
Sadao Kikuta ◽  
Shinji Yamashita ◽  
Kunio Nakanishi ◽  
...  
Keyword(s):  
Rat Brain ◽  
Regional Distribution ◽  
Elimination Kinetics ◽  
Kinetics Of

Theophylline Toxicity in a Premature Neonate – Elimination Kinetics of Exchange Transfusion

1993 ◽  
Vol 31 (4) ◽  
pp. 639-644 ◽  
Author(s):  
Harold H. Osborn ◽  
Glendon Henry ◽  
Paul Wax ◽  
Robert Hoffman ◽  
Mary Ann Howland
Keyword(s):  
Exchange Transfusion ◽  
Premature Neonate ◽  
Elimination Kinetics ◽  
Kinetics Of

The Influence of Surgery on the Elimination Kinetics of Disopyramide in Pigs

2009 ◽  
Vol 59 (1) ◽  
pp. 86-88
Author(s):  
L. E. Pedersen ◽  
K. Hermansen ◽  
H. O. Olesen ◽  
S. N. Rasmussen
Keyword(s):  
Elimination Kinetics ◽  
Kinetics Of
Sign in / Sign up

Export Citation Format

Share Document