AUGMENTATION OF TISSUE WATER PROTON SPIN-LATTICE RELAXATION RATES BY IN VIVO ADDITION OF PARAMAGNETIC IONS

1978 ◽  
pp. 752-759 ◽  
Author(s):  
Paul C. Lauterbur ◽  
M. Helena Mendonça Dias ◽  
Andrew M. Rudin
Keyword(s):  
Lattice Relaxation ◽  
Proton Spin ◽  
Spin Lattice Relaxation ◽  
Water Proton ◽  
Relaxation Rates ◽  
Tissue Water ◽  
Spin Lattice ◽  
Paramagnetic Ions

A new approach to cancer treatment

2014 ◽  
Vol 14 (1) ◽  
pp. 99-101 ◽  
Author(s):  
Syed F. Akber
Keyword(s):  
Radiation Treatment ◽  
Lattice Relaxation ◽  
Lattice Relaxation Time ◽  
Proton Spin ◽  
Ionising Radiation ◽  
Spin Lattice Relaxation ◽  
Water Proton ◽  
New Approach ◽  
Spin Lattice

AbstractA new approach is applied to correlate different phases of the HeLa cell S-3 with mean lethal ionising radiation dose (Do) along with nuclear magnetic resonance water-proton spin-lattice relaxation time (T1). This information can be used to pin-point the mitotic phase of the cells in vivo. This enables us to apply ionising radiation treatment at that particular time. This will increase the efficacy of radiation treatment in cancer patients.

Role of Paramagnetic Ions and Water Proton Spin-Lattice Relaxation Time in Biological Systems

1993 ◽  
Vol 32 (01) ◽  
pp. 52-56 ◽  
Author(s):  
S. F. Akber
Keyword(s):  
Relaxation Times ◽  
Lattice Relaxation ◽  
Lattice Relaxation Time ◽  
Proton Spin ◽  
Spin Lattice Relaxation ◽  
Manganese Concentration ◽  
Water Proton ◽  
Manganese Ion ◽  
Spin Lattice ◽  
Paramagnetic Ions

SummaryThis paper summarizes the observations of different studies concerning the influence of paramagnetic ions on spin-lattice relaxation times in magnetic resonance imaging. Based on findings that manganese ion content in cancer tissues is decreased in comparison to normal tissues, the results of different papers analysing the influence of tissue manganese concentration on spin- lattice relaxation times are collected and compared. Neither the comparison between different organs, different animals nor the comparison between different tissues (normal and malignant) showed correlations of practical consequences between manganese concentrations and spin-lattice relaxation times. These results are consistent with those from studies with copper and iron ions in living systems.

An experimental evaluation of simplified procedures for determining the proton spin–lattice relaxation rates of natural products

1980 ◽  
Vol 58 (19) ◽  
pp. 2016-2023 ◽  
Author(s):  
Lawrence D. Colebrook ◽  
Laurance D. Hall
Keyword(s):  
Natural Products ◽  
Lattice Relaxation ◽  
Null Point ◽  
Proton Spin ◽  
Computational Method ◽  
Spin Lattice Relaxation ◽  
Relaxation Rates ◽  
Spin Lattice ◽  
Simplified Procedures

A general discussion is given of the determination of the proton spin–lattice relaxation rates of natural products, with particular emphasis on use of the null-point method which, for the systems studied here, gives identical results with those obtained via the conventional (and relatively time consuming) computational method.

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