Synthesis and applications of backbone-fluorinated amino acids

2019 ◽  
pp. 325-347
Author(s):  
Flora Mansour ◽  
Luke Hunter
Keyword(s):  
Amino Acids ◽  
Fluorinated Amino Acids

scholarly journals Evaluating electronic structure methods for accurate calculation of 19 F chemical shifts in fluorinated amino acids

2017 ◽  
Vol 38 (30) ◽  
pp. 2605-2617 ◽  
Author(s):  
Jayangika N. Dahanayake ◽  
Chandana Kasireddy ◽  
Jonathan M. Ellis ◽  
Derek Hildebrandt ◽  
Olivia A. Hull ◽  
...  
Keyword(s):  
Amino Acids ◽  
Electronic Structure ◽  
Chemical Shifts ◽  
Accurate Calculation ◽  
Fluorinated Amino Acids ◽  
Electronic Structure Methods

scholarly journals Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids (Adv. Funct. Mater. 40/2021)

2021 ◽  
Vol 31 (40) ◽  
pp. 2170300
Author(s):  
Janna N. Sloand ◽  
Tyler E. Culp ◽  
Nichole M. Wonderling ◽  
Enrique D. Gomez ◽  
Scott H. Medina
Keyword(s):  
Amino Acids ◽  
Interfacial Assembly ◽  
Fluorinated Amino Acids

scholarly journals Chemical aminoacylation of tRNAs with fluorinated amino acids for in vitro protein mutagenesis

2010 ◽  
Vol 6 ◽  
Author(s):  
Shijie Ye ◽  
Allison Ann Berger ◽  
Dominique Petzold ◽  
Oliver Reimann ◽  
Benjamin Matt ◽  
...  
Keyword(s):  
Amino Acids ◽  
Translation System ◽  
Biologically Relevant ◽  
Fluorinated Amino Acids ◽  
Free Translation ◽  
Trna Species ◽  
A Cell ◽  
Protein Environment ◽  
Vitro Protein

This article describes the chemical aminoacylation of the yeast phenylalanine suppressor tRNA with a series of amino acids bearing fluorinated side chains via the hybrid dinucleotide pdCpA and ligation to the corresponding truncated tRNA species. Aminoacyl-tRNAs can be used to synthesize biologically relevant proteins which contain fluorinated amino acids at specific sites by means of a cell-free translation system. Such engineered proteins are expected to contribute to our understanding of discrete fluorines’ interaction with canonical amino acids in a native protein environment and to enable the design of fluorinated proteins with arbitrary desired properties.

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