Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins

2009 ◽  
pp. 389-409 ◽  
Author(s):  
Mario Salwiczek ◽  
Toni Vagt ◽  
Beate Koksch
Keyword(s):  
Amino Acids ◽  
Coiled Coil ◽  
Model Systems ◽  
Fluorinated Amino Acids ◽  
Artificial Model

Towards identifying preferred interaction partners of fluorinated amino acids within the hydrophobic environment of a dimeric coiled coil peptide

2010 ◽  
Vol 8 (6) ◽  
pp. 1382 ◽  
Author(s):  
Toni Vagt ◽  
Elisabeth Nyakatura ◽  
Mario Salwiczek ◽  
Christian Jäckel ◽  
Beate Koksch
Keyword(s):  
Amino Acids ◽  
Coiled Coil ◽  
Fluorinated Amino Acids ◽  
Interaction Partners

scholarly journals Position-Dependent Effects of Fluorinated Amino Acids on the Hydrophobic Core Formation of a Heterodimeric Coiled Coil

2009 ◽  
Vol 15 (31) ◽  
pp. 7628-7636 ◽  
Author(s):  
Mario Salwiczek ◽  
Sergey Samsonov ◽  
Toni Vagt ◽  
Elisabeth Nyakatura ◽  
Emanuel Fleige ◽  
...  
Keyword(s):  
Amino Acids ◽  
Coiled Coil ◽  
Hydrophobic Core ◽  
Core Formation ◽  
Fluorinated Amino Acids

scholarly journals Evaluating electronic structure methods for accurate calculation of 19 F chemical shifts in fluorinated amino acids

2017 ◽  
Vol 38 (30) ◽  
pp. 2605-2617 ◽  
Author(s):  
Jayangika N. Dahanayake ◽  
Chandana Kasireddy ◽  
Jonathan M. Ellis ◽  
Derek Hildebrandt ◽  
Olivia A. Hull ◽  
...  
Keyword(s):  
Amino Acids ◽  
Electronic Structure ◽  
Chemical Shifts ◽  
Accurate Calculation ◽  
Fluorinated Amino Acids ◽  
Electronic Structure Methods

scholarly journals Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids (Adv. Funct. Mater. 40/2021)

2021 ◽  
Vol 31 (40) ◽  
pp. 2170300
Author(s):  
Janna N. Sloand ◽  
Tyler E. Culp ◽  
Nichole M. Wonderling ◽  
Enrique D. Gomez ◽  
Scott H. Medina
Keyword(s):  
Amino Acids ◽  
Interfacial Assembly ◽  
Fluorinated Amino Acids

scholarly journals Chemical aminoacylation of tRNAs with fluorinated amino acids for in vitro protein mutagenesis

2010 ◽  
Vol 6 ◽  
Author(s):  
Shijie Ye ◽  
Allison Ann Berger ◽  
Dominique Petzold ◽  
Oliver Reimann ◽  
Benjamin Matt ◽  
...  
Keyword(s):  
Amino Acids ◽  
Translation System ◽  
Biologically Relevant ◽  
Fluorinated Amino Acids ◽  
Free Translation ◽  
Trna Species ◽  
A Cell ◽  
Protein Environment ◽  
Vitro Protein

This article describes the chemical aminoacylation of the yeast phenylalanine suppressor tRNA with a series of amino acids bearing fluorinated side chains via the hybrid dinucleotide pdCpA and ligation to the corresponding truncated tRNA species. Aminoacyl-tRNAs can be used to synthesize biologically relevant proteins which contain fluorinated amino acids at specific sites by means of a cell-free translation system. Such engineered proteins are expected to contribute to our understanding of discrete fluorines’ interaction with canonical amino acids in a native protein environment and to enable the design of fluorinated proteins with arbitrary desired properties.

Sign in / Sign up

Export Citation Format

Share Document