Physiologically based pharmacokinetic models to support modernized chemical safety assessment

Physiologically Based Pharmacokinetic (PBPK) Modeling ◽

10.1016/b978-0-12-818596-4.00012-6 ◽

2020 ◽

pp. 301-321

Author(s):

Miyoung Yoon

Keyword(s):

Safety Assessment ◽

Pharmacokinetic Models ◽

Chemical Safety ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Pesticide Exposures ◽

Physiologically Based

Download Full-text

Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

Download Full-text

Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-16 ◽

2006 ◽

pp. 301-348 ◽

Author(s):

Robert De Woskin ◽

Chadwick Thompson ◽

Weihsueh Chiu ◽

Paul Schlosser ◽

Carolyn Smallwood ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Integrated Risk ◽

Physiologically Based

Download Full-text

Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

The AAPS Journal ◽

10.1208/s12248-015-9796-7 ◽

2015 ◽

Vol 17 (5) ◽

pp. 1268-1279 ◽

Author(s):

Helen Musther ◽

Katherine L. Gill ◽

Manoranjenni Chetty ◽

Amin Rostami-Hodjegan ◽

Malcolm Rowland ◽

...

Keyword(s):

Sampling Site ◽

Pharmacokinetic Models ◽

Central Venous ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Download Full-text

Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology ◽

10.1016/b978-0-12-804239-7.00004-4 ◽

2017 ◽

pp. 51-65

Author(s):

Kannan Krishnan ◽

Sandrine Fleur Chebekoue

Keyword(s):

Pharmacokinetic Models ◽

Developmental Toxicology ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0685-y ◽

2018 ◽

Vol 58 (2) ◽

pp. 235-262 ◽

Author(s):

Khaled Abduljalil ◽

Masoud Jamei ◽

Trevor N. Johnson

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Download Full-text

Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.03.032 ◽

2017 ◽

Vol 106 (9) ◽

pp. 2758-2770 ◽

Author(s):

Hoa Q. Nguyen ◽

Jian Lin ◽

Emi Kimoto ◽

Ernesto Callegari ◽

Susanna Tse ◽

...

Keyword(s):

Carboxylic Acid ◽

Pharmacokinetic Models ◽

Acid Metabolite ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Utility of Quantitative Proteomics for Enhancing the Predictive Ability of Physiologically Based Pharmacokinetic Models Across Disease States

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1709 ◽

2020 ◽

Vol 60 (S1) ◽

Author(s):

Sheena Sharma ◽

Deepak Suresh Ahire ◽

Bhagwat Prasad

Keyword(s):

Quantitative Proteomics ◽

Predictive Ability ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Disease States ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Construction and Verification of Physiologically Based Pharmacokinetic Models for Four Drugs Majorly Cleared by Glucuronidation: Lorazepam, Oxazepam, Naloxone, and Zidovudine

The AAPS Journal ◽

10.1208/s12248-020-00513-5 ◽

2020 ◽

Vol 22 (6) ◽

Author(s):

Luca Docci ◽

Kenichi Umehara ◽

Stephan Krähenbühl ◽

Stephen Fowler ◽

Neil Parrott

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text