Overview of Malignant Pleural Neoplasms

Author(s):  
Saul Suster ◽  
Cesar A. Moran
Keyword(s):  
1987 ◽  
Vol 53 (1) ◽  
pp. 146-152 ◽  
Author(s):  
Inchul Lee ◽  
Victor E. Gould ◽  
James A. Radosevich ◽  
Ann Thor ◽  
Yixing Ma ◽  
...  

2010 ◽  
Vol 17 (3) ◽  
pp. 113-114 ◽  
Author(s):  
George Rakovich ◽  
Maxime Laflamme ◽  
Denise Ouellette ◽  
Gilles Beauchamp

Solitary fibrous tumours of the pleura are rare pleural neoplasms that are distinct from mesothelioma. Most of them are benign, although some behave aggressively; morphological and pathological features are important in distinguishing them from mesothelioma and in predicting clinical behaviour. Solitary fibrous tumours often grow to a large size before causing symptoms, and are characteristically associated with hypertrophic pulmonary osteoarthropathy in up to 20% of cases. In cases of benign lesions, complete resection is usually curative. A case involving a 62-year-old woman who underwent surgical resection of a solitary fibrous tumour of the pleura measuring 25 cm in size is described.


Tumor Biology ◽  
1989 ◽  
Vol 10 (6) ◽  
pp. 281-288 ◽  
Author(s):  
J.A. Radosevich ◽  
P.G. Robinson ◽  
W.P. Carney ◽  
W. Warren ◽  
S.T. Rosen ◽  
...  

Author(s):  
Philip T. Cagle ◽  
Jaishree Jagirdar ◽  
Helmut H. Popper

2008 ◽  
Vol 132 (7) ◽  
pp. 1062-1072 ◽  
Author(s):  
Mary Beth Beasley

Abstract Context.—The use of immunohistochemical stains has several applications in the evaluation of pulmonary and pleural neoplasms. The number of available immunohistochemical stains is continually expanding and, although these stains are an important diagnostic adjunct, their use is not without limitations and pitfalls. Objective.—To review and summarize the primary immunohistochemical applications with regard to the most common pulmonary and pleural neoplasms and discuss newly developed markers and common pitfalls. Data Sources.—Pertinent peer-reviewed literature emphasizing immunohistochemical applications in common lung and pleural tumors, unusual and problematic staining patterns in frequently encountered subtypes/histologic variants, and recently developed immunohistochemical stains of potential promise. Conclusions.—Immunohistochemical stains provide the greatest aid in establishing the site of origin of adenocarcinomas encountered in the lung and in separating epithelioid mesothelioma from adenocarcinoma. Certain subtypes of pulmonary adenocarcinomas may exhibit unusual staining patterns that may be potentially problematic. Immunohistochemistry has a more limited role in separating small cell carcinoma from non–small cell carcinoma, and extreme caution must be used in the situation of crushed biopsy specimens.


2008 ◽  
Vol 132 (7) ◽  
pp. 1149-1170 ◽  
Author(s):  
Donald G. Guinee ◽  
Timothy Craig Allen

Abstract Context.—Overwhelmingly, the most common neoplasm involving the pleura is metastatic carcinoma. In contrast, diffuse malignant mesothelioma occurs relatively rarely; however, it is nonetheless the most common neoplasm primary to the pleura. Metastatic carcinoma and diffuse malignant mesothelioma each have their own prognostic and therapeutic characteristics. Other primary pleural neoplasms occur uncommonly or rarely, with their own prognostic and therapeutic characteristics. Objective.—To review primary pleural neoplasms other than diffuse malignant mesothelioma, to better ensure correct diagnosis and optimal assessment of prognosis and treatment. Data Sources.—Literature review and primary material from the authors' institutions. Conclusions.—A nonexhaustive group of uncommon to rare benign and malignant primary pleural neoplasms— other than diffuse malignant mesothelioma—are presented, of which one must be aware in order to maintain an appropriate index of suspicion to include them in the differential diagnosis of a pleural tumor.


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