Human induced pluripotent stem cell– based modeling of Alzheimer’s disease, a glial perspective

2021 ◽  
pp. 21-35
Author(s):  
Xianwei Chen ◽  
Qingqiu Yang ◽  
Zhenqing Liu ◽  
Yanhong Shi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Induced Pluripotent

scholarly journals Generation of induced pluripotent stem cell line (ZZUi0013-A) from a 65-year-old patient with a novel MEOX2 gene mutation in Alzheimer's disease

2019 ◽  
Vol 34 ◽  
pp. 101366
Author(s):  
Yanlin Wang ◽  
Huifang Sun ◽  
Jing Yang ◽  
Changhe Shi ◽  
Yutao Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cell Line ◽  
Gene Mutation ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Stem Cell Line ◽  
Induced Pluripotent

scholarly journals NEUBOrg: artificially induced pluripotent stem cell-derived brain organoid to model and study genetics of Alzheimer’s disease progression.

2020 ◽  
Author(s):  
Sally Esmail ◽  
Wayne Danter
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Disease Progression ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Whole Brain ◽  
Learning Platform ◽  
Brain Organoid ◽  
Induced Pluripotent

Abstract Alzheimer's disease (AD) is the most common type of neurodegenerative diseases. There are over 44 million people living with the disease worldwide. While there are currently no effective treatments for AD, induced pluripotent stem cell-derived brain organoids have the potential to provide a better understanding of Alzheimer’s pathogenesis. Nevertheless, developing brain organoid models is expensive, time consuming and often does not reflect disease progression. Using accurate and inexpensive computer simulations of human brain organoids can overcome the current limitations. Induced whole brain organoids (aiWBO) will greatly expand our ability to model AD and can guide wet lab research. In this study, we have successfully developed and validated artificially induced a whole brain organoid platform (NEUBOrg) using our previously validated machine learning platform, DeepNEU (v6.1). Using NEUBorg platform, we have generated aiWBO simulations of AD and provided a novel approach to test genetic risk factors associated with AD progression and pathogenesis.

Human Induced Pluripotent Stem Cell-Derived Neural Cells from Alzheimer's Disease Patients Exhibited Different Susceptibility to Oxidative Stress

2020 ◽  
Vol 29 (22) ◽  
pp. 1444-1456 ◽  
Author(s):  
Lin Zhang ◽  
Mei Xu ◽  
Qiao Ren ◽  
Gang Liu ◽  
Shulin Meng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Neural Cells ◽  
Induced Pluripotent

scholarly journals Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with sporadic Alzheimer's disease

2016 ◽  
Vol 17 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Anna Ochalek ◽  
Csilla Nemes ◽  
Eszter Varga ◽  
Zsuzsanna Táncos ◽  
Julianna Kobolák ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Ipsc Line ◽  
Sporadic Alzheimer’S Disease ◽  
Induced Pluripotent

scholarly journals The expression of P2X7 receptor in human induced pluripotent stem cell‐derived cellular model of Alzheimer’s disease

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Linda Francistiova ◽  
Annamária Téglási ◽  
Zsófia Kern ◽  
Julianna Kobolák ◽  
András Dinnyés
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
P2x7 Receptor ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Cellular Model ◽  
Model Of Alzheimer’S Disease ◽  
Induced Pluripotent

scholarly journals Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD)

2016 ◽  
Vol 17 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Zsuzsanna Táncos ◽  
Eszter Varga ◽  
Eszter Kovács ◽  
András Dinnyés ◽  
Julianna Kobolák
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Late Onset ◽  
Induced Pluripotent Stem Cell ◽  
Ipsc Line ◽  
Induced Pluripotent

scholarly journals Characterization of human induced pluripotent stem cell (iPSC) line from a 72 year old male patient with later onset Alzheimer's disease

2017 ◽  
Vol 19 ◽  
pp. 34-36 ◽  
Author(s):  
Shaokun Zhang ◽  
Zhenshan Lv ◽  
Songyuan Zhang ◽  
Lidi Liu ◽  
Qiao Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Male Patient ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Ipsc Line ◽  
Induced Pluripotent

scholarly journals N-butylidenephthalide Attenuates Alzheimer's Disease-Like Cytopathy in Down Syndrome Induced Pluripotent Stem Cell-Derived Neurons

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Chia-Yu Chang ◽  
Sheng-Mei Chen ◽  
Huai-En Lu ◽  
Syu-Ming Lai ◽  
Ping-Shan Lai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Induced Pluripotent
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