The Role of Trace Elements in Nucleic Acid Metabolism and Protein Synthesis

1984 ◽  
pp. 51-67
Keyword(s):  
Trace Elements ◽  
Protein Synthesis ◽  
Nucleic Acid ◽  
Acid Metabolism ◽  
Nucleic Acid Metabolism

scholarly journals Proliferation of Megaloblasts in Pernicious Anemia as Observed from Nucleic Acid Metabolism

Blood ◽  
1968 ◽  
Vol 31 (3) ◽  
pp. 292-303 ◽  
Author(s):  
YATARO YOSHIDA ◽  
AKIO TODO ◽  
SHIGERU SHIRAKAWA ◽  
GYOICHI WAKISAKA ◽  
HARUTO UCHINO
Keyword(s):  
Protein Synthesis ◽  
Nucleic Acid ◽  
Pernicious Anemia ◽  
Acid Metabolism ◽  
Cellular Level ◽  
The Other ◽  
Nucleic Acid Metabolism ◽  
Dna Values ◽  
Rna And Protein Synthesis ◽  
S Period

Abstract In order to elucidate the nature of the megaloblastic lesion at the cellular level, DNA, RNA, and protein synthesis was studied in megaloblasts of pernicious anemia. While microphotometric estimation of DNA content showed an increase in cells with DNA values ranging around the 4c value, autoradiographic studies with H3-thymidine indicated, rather, a decreased ability to synthesize DNA. Combined microphotometric and autoradiographic studies suggested the impaired DNA synthesis with occasional arrests of synthesis, as well as the prolongation of the S period with or without the prolongation of the G2 period. On the other hand, active incorporation of H3-uridine and H3-leucine indicated active or unaffected RNA and protein synthesis. Vitamin B12 treatment rapidly corrected these aberrant patterns of synthesis. The significance of these findings has been discussed in relation to the mechanism of megaloblastic hemopoiesis.

EFFECT OF OESTRADIOL-17β ON CLEAVAGE, NUCLEIC ACID METABOLISM AND PROTEIN SYNTHESIS IN SEA URCHIN, STRONGYLOCENTROTUS PURPURATUS, EMBRYOS

1962 ◽  
Vol 25 (2) ◽  
pp. 183-NP ◽  
Author(s):  
W. B. JOLLEY ◽  
W. E. MARTIN ◽  
J. W. BAMBERGER ◽  
L. W. STEARNS
Keyword(s):  
Protein Synthesis ◽  
Nucleic Acid ◽  
Sea Urchin ◽  
Ribonucleic Acid ◽  
Deoxyribonucleic Acid ◽  
Acid Metabolism ◽  
Strongylocentrotus Purpuratus ◽  
Nucleic Acid Metabolism ◽  
Dna And Rna ◽  
Moderate Effect

SUMMARY Oestradiol-17β at a concentration of 3 × 10−3 m inhibits cleavage in sea urchin (Strongylocentrotus purpuratus) embryos. This inhibition is accompanied by a reduction in deoxyribonucleic acid (DNA) synthesis and little change in ribonucleic acid (RNA). The effects of oestradiol-17β upon the incorporation of glycine-1-14C and glycine-2-14C into the purines of DNA and RNA and the incorporation of glycine-2-14C into serine were studied. The incorporation of glycine-1-14C and glycine-2-14C into RNA was reduced, but the incorporation of glycine-2-14C into DNA was increased considerably over that of the controls. The incorporation of glycine-2-14C into serine was also accelerated by oestradiol. A possible explanation of the action of oestradiol-17β is offered. The moderate effect upon RNA is not surprising because there is little or no synthesis of this compound from the time of fertilization to blastulation under normal conditions.

scholarly journals ROLE OF VITAMIN B12 IN NUCLEIC ACID METABOLISM

1956 ◽  
Vol 220 (2) ◽  
pp. 513-520 ◽  
Author(s):  
Mancourt Downing ◽  
B.S. Schweigert
Keyword(s):  
Nucleic Acid ◽  
Vitamin B12 ◽  
Acid Metabolism ◽  
Nucleic Acid Metabolism

Role of Vitamin B12 in Nucleic Acid Metabolism

1956 ◽  
Vol 58 (2) ◽  
pp. 231-242 ◽  
Author(s):  
W. T. Wong ◽  
B. S. Schweigert
Keyword(s):  
Nucleic Acid ◽  
Vitamin B12 ◽  
Acid Metabolism ◽  
Nucleic Acid Metabolism

scholarly journals ROLE OF VITAMIN B12 IN NUCLEIC ACID METABOLISM

1956 ◽  
Vol 220 (2) ◽  
pp. 521-526
Author(s):  
Mancourt Downing ◽  
B.S. Schweigert
Keyword(s):  
Nucleic Acid ◽  
Vitamin B12 ◽  
Acid Metabolism ◽  
Nucleic Acid Metabolism
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