scholarly journals Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

Stem Cells ◽  
2010 ◽  
Vol 28 (10) ◽  
pp. 1893-1904 ◽  
Author(s):  
Andrzej Swistowski ◽  
Jun Peng ◽  
Qiuyue Liu ◽  
Prashant Mali ◽  
Mahendra S. Rao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Dopaminergic Neurons ◽  
Efficient Generation ◽  
Induced Pluripotent

scholarly journals Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells Survive and Integrate into 6-OHDA-Lesioned Rats

2010 ◽  
Vol 19 (7) ◽  
pp. 1017-1023 ◽  
Author(s):  
Jingli Cai ◽  
Ming Yang ◽  
Elizabeth Poremsky ◽  
Sarah Kidd ◽  
Jay S. Schneider ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Dopaminergic Neurons ◽  
Induced Pluripotent

Building authentic midbrain dopaminergic neurons from stem cells - lessons from development

2012 ◽  
Vol 3 (4) ◽  
Author(s):  
Agnete Kirkeby ◽  
Malin Parmar
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Dopaminergic Neurons ◽  
Human Pluripotent Stem Cells ◽  
Developmental Pathways ◽  
Significant Progress ◽  
Pluripotent Cells ◽  
Generate Functional ◽  
Midbrain Dopaminergic Neurons ◽  
One Step

AbstractThe challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson’s disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.

scholarly journals Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells

2018 ◽  
Vol 4 ◽  
pp. e25423
Author(s):  
Cheng Lin
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Dopaminergic Neurons ◽  
Lewy Body ◽  
Lewy Bodies ◽  
Transmission Mechanism ◽  
Induced Pluripotent

Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is proposed to investigate the transmission mechanism of α-synuclein pathology using PD patient-derived human induced pluripotent stem cells (hiPSC) in an in vitro human cellular and molecular PD model and in vivo mouse PD model for dopaminergic neuron transplantation.

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