Challenges and Opportunities in Pharmaceutical Manufacturing Modeling and Optimization

2014 ◽  
pp. 144-149 ◽  
Author(s):  
Amanda Rogers ◽  
Marianthi Ierapetritou
Keyword(s):  
Pharmaceutical Manufacturing ◽  
Modeling And Optimization ◽  
Challenges And Opportunities

scholarly journals Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 457
Author(s):  
Miriam Sarkis ◽  
Andrea Bernardi ◽  
Nilay Shah ◽  
Maria M. Papathanasiou
Keyword(s):  
Systems Engineering ◽  
Drug Product ◽  
High Specificity ◽  
Supply Chain Design ◽  
Pharmaceutical Manufacturing ◽  
Research Directions ◽  
Process Systems ◽  
Challenges And Opportunities ◽  
Complex Drug

The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for seamless communication between process units, plants, and distribution nodes. In this paper, we discuss how novel therapeutics of high-specificity and sensitive nature are reshaping well-established paradigms in the pharmaceutical industry. We present an overview of recent research directions in pharmaceutical manufacturing and supply chain design and operations. We discuss topical challenges and opportunities related to small molecules and biologics, dividing the latter into patient- and non-specific. Lastly, we present the role of process systems engineering in generating decision-making tools to assist manufacturing and distribution strategies in the pharmaceutical sector and ultimately embrace the benefits of digitalised operations.

scholarly journals Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

2020 ◽  
Author(s):  
Matthew J. McNulty ◽  
Yongao Xiong ◽  
Kevin Yates ◽  
Kalimuthu Karuppanan ◽  
Jacob M. Hilzinger ◽  
...  
Keyword(s):  
Life Support ◽  
Selection Process ◽  
Human Life ◽  
Pharmaceutical Manufacturing ◽  
Molecular Pharming ◽  
Medical Systems ◽  
Widespread Application ◽  
Human System ◽  
Challenges And Opportunities ◽  
System Risk

Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical system. Space agencies can no longer buy down the majority of human system risk through the crew member selection process and emergency re-supply or evacuation. No mature medical solutions exist to close the risk gap. With recent advances in biotechnology, there is promise in augmenting a space pharmacy with a biologically-based space foundry for on-demand manufacturing of high-value medical products. Here we review the challenges and opportunities of molecular pharming, the production of pharmaceuticals in plants, as the basis of a space medical foundry to close the risk gap in current space medical systems. Plants have long been considered an important life support object in space and can now also be viewed as programmable factories in space. Advances in molecular pharming-based space foundries will have widespread application in promoting simple and accessible pharmaceutical manufacturing on Earth.

Continuous hydrogenolysis of acetal-stabilized lignin in flow

2021 ◽  
Author(s):  
Wu Lan ◽  
Yuan Peng Du ◽  
Songlan Sun ◽  
Jean Behaghel de Bueren ◽  
Florent Héroguel ◽  
...  
Keyword(s):  
Steady State ◽  
Challenges And Opportunities

We performed a steady state high-yielding depolymerization of soluble acetal-stabilized lignin in flow, which offered a window into challenges and opportunities that will be faced when continuously processing this feedstock.

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