AbstractIn this paper we numerically investigate a model of a diffusively coupled ring of cells. To model the dynamics of individual cells we propose a map with cell affinity, which is a generalization of the logistic map. First, the basic features of a one-cell system are studied in terms of the Lyapunov exponent, Kolmogorov complexity and Sample Entropy. Second, the notion of observational heterarchy, which is a perpetual negotiation process between different levels of the description of a phenomenon, is reviewed. After these preliminaries, we study how the active coupling induced by the consideration of the observational heterarchy modifies the synchronization property of the model with N=100 cells. It is shown numerically that the active coupling enhances synchronization of biochemical substance exchange in several different conditions of cell affinity.
Biosensors for the Multiplex Detection of Inflammatory Disease Biomarkers