Commentary on and reprint of Castle WB, Observations of the etiologic relationship of achylia gastrica to pernicious anemia. The effect of the administration to patients with pernicious anemia of the contents of the normal human stomach recovered after the ingestion of beef muscle, in American Journal of the Medical Sciences (1929) 178:748–763

Hematology ◽  
2000 ◽  
pp. 407-423
Author(s):  
M LICHTMAN ◽  
J SPIVAK ◽  
L BOXER ◽  
S SHATTIL ◽  
E HENDERSON
Keyword(s):  
Pernicious Anemia ◽  
Human Stomach ◽  
Medical Sciences ◽  
Normal Human ◽  
Relationship Of ◽  
Etiologic Relationship ◽  
Beef Muscle

scholarly journals Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia

Blood ◽  
1951 ◽  
Vol 6 (3) ◽  
pp. 228-232 ◽  
Author(s):  
ROBERT F. SCHILLING ◽  
JOHN W. HARRIS ◽  
WILLIAM B. CASTLE
Keyword(s):  
Spinal Cord ◽  
Oral Administration ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Human Gastric Juice ◽  
Vitamin B12b ◽  
Normal Human ◽  
Relationship Of ◽  
Etiologic Relationship ◽  
Hematopoietic Activity

Abstract 1. Vitamin B12a, derived from vitamin B12 by catalytic hydrogenation, is as potent a hematopoietic agent as vitamin B12 when administered parenterally to patients with pernicious anemia in relapse. 2. The hematopoietic activity of vitamin B12a, like that of vitamin B12, and of vitamin B12b, is potentiated by simultaneous oral administration with normal human gastric juice. 3. Observations on one patient suggest that vitamin B12a, like vitamin B12, will arrest the progress of subacute degeneration of the spinal cord in pernicious anemia.

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