scholarly journals OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA. VIII. FURTHER STUDIES OF THE PROTEOLYTIC ACTIVITY OF NORMAL HUMAN GASTRIC JUICE IN VITRO; AND THE LIMITATIONS OF THE METHOD IN PERNICIOUS ANEMIA 1

1940 ◽  
Vol 19 (1) ◽  
pp. 225-231 ◽  
Author(s):  
C. J. Gessler ◽  
S. O. Dexter ◽  
Margaret A. Adams ◽  
F. H. L. Taylor
Keyword(s):  
Pernicious Anemia ◽  
Gastric Juice ◽  
Proteolytic Activity ◽  
Human Gastric Juice ◽  
Normal Human ◽  
Relationship Of ◽  
Etiologic Relationship

scholarly journals Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia

Blood ◽  
1951 ◽  
Vol 6 (3) ◽  
pp. 228-232 ◽  
Author(s):  
ROBERT F. SCHILLING ◽  
JOHN W. HARRIS ◽  
WILLIAM B. CASTLE
Keyword(s):  
Spinal Cord ◽  
Oral Administration ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Human Gastric Juice ◽  
Vitamin B12b ◽  
Normal Human ◽  
Relationship Of ◽  
Etiologic Relationship ◽  
Hematopoietic Activity

Abstract 1. Vitamin B12a, derived from vitamin B12 by catalytic hydrogenation, is as potent a hematopoietic agent as vitamin B12 when administered parenterally to patients with pernicious anemia in relapse. 2. The hematopoietic activity of vitamin B12a, like that of vitamin B12, and of vitamin B12b, is potentiated by simultaneous oral administration with normal human gastric juice. 3. Observations on one patient suggest that vitamin B12a, like vitamin B12, will arrest the progress of subacute degeneration of the spinal cord in pernicious anemia.

scholarly journals The pepsins of normal human gastric juice

1969 ◽  
Vol 113 (4) ◽  
pp. 663-668 ◽  
Author(s):  
D J Etherington ◽  
W H Taylor
Keyword(s):  
Gastric Juice ◽  
Proteolytic Activity ◽  
Gel Electrophoresis ◽  
Normal Subjects ◽  
Frequency Of Occurrence ◽  
Agar Gel ◽  
Human Gastric Juice ◽  
Normal Human ◽  
Agar Gel Electrophoresis ◽  
A Minor

1. The frequency of occurrence, under defined conditions, of the different human pepsins in the gastric juices of 50 normal subjects was investigated by agar-gel electrophoresis. 2. From a total of eight proteolytic zones located in the zymograms, no significant differences of occurrence existed between the sexes, or between subjects with or without gastric symptoms. 3. Two zones, numbered 3 and 5, occurred in all normal gastric juices. Zone 3 always exhibited the greatest proteolytic activity, then zone 5. The remaining enzymic zones were less well-marked and occurred less frequently. 4. A minor zone, 3a, was demonstrated within zone 3. The corresponding pepsin, 3a, has a mobility towards the anode 6–7% greater than has pepsin 3. 5. Of the eight zones, 1,2,3,3a and 5, at least, represent unique pepsins.

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