scholarly journals Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia

Blood ◽  
1951 ◽  
Vol 6 (3) ◽  
pp. 228-232 ◽  
Author(s):  
ROBERT F. SCHILLING ◽  
JOHN W. HARRIS ◽  
WILLIAM B. CASTLE
Keyword(s):  
Spinal Cord ◽  
Oral Administration ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Human Gastric Juice ◽  
Vitamin B12b ◽  
Normal Human ◽  
Relationship Of ◽  
Etiologic Relationship ◽  
Hematopoietic Activity

Abstract 1. Vitamin B12a, derived from vitamin B12 by catalytic hydrogenation, is as potent a hematopoietic agent as vitamin B12 when administered parenterally to patients with pernicious anemia in relapse. 2. The hematopoietic activity of vitamin B12a, like that of vitamin B12, and of vitamin B12b, is potentiated by simultaneous oral administration with normal human gastric juice. 3. Observations on one patient suggest that vitamin B12a, like vitamin B12, will arrest the progress of subacute degeneration of the spinal cord in pernicious anemia.

A case report on Subacute Combined Degeneration of spinal cord in children – A rare neurological manifestation in Vitamin B12 deficiencies

2017 ◽  
Vol 6 (12) ◽  
pp. 5562
Author(s):  
Tiana Mary Alexander ◽  
Vineeta Pande ◽  
Sharad Agarkhedkar ◽  
Dnyaneshwar Upase
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Chronic Diarrhea ◽  
Megaloblastic Anemia ◽  
Vegetarian Diet ◽  
Malabsorption Syndrome ◽  
Subacute Combined Degeneration ◽  
B12 Deficiency

Megaloblastic anemia is a common feature between 6 months – 2 years and rarely occurs after 5 years of age, especially in a child consuming non-vegetarian diet. B12 deficiency may occur after 5 years of age because of chronic diarrhea, malabsorption syndrome, or intestinal surgical causes. Pernicious anemia causes B12 deficiency, but nutritional B12 deficiency with subacute combined degeneration causing ataxia is rare.

scholarly journals Megaloblastic Anemia Associated with Anatomic Lesions in the Small Intestine

Blood ◽  
1955 ◽  
Vol 10 (8) ◽  
pp. 771-787 ◽  
Author(s):  
R. B. THOMPSON ◽  
C. C. UNGLEY
Keyword(s):  
Small Intestine ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Megaloblastic Anemia ◽  
The Other ◽  
Intestinal Lesion ◽  
Laboratory Findings ◽  
Relationship Of ◽  
The Relationship

Abstract This paper describes the development of anemia in six patients with strictures and anastomoses in the small intestine. The marrow proved to be megaloblastic in three instances, and megaloblastic change is presumed in the other three because of the clinical and laboratory findings, and the characteristic hemopoietic response to liver therapy. Responses to crude and refined liver extracts and vitamin B12 compared unfavorably with those to be expected in Addisonian pernicious anemia; they were similar to the poorer responses often observed in megaloblastic anemia associated with idiopathic steatorrhea. The relationship of the intestinal lesion to the development of megaloblastic anemia is briefly discussed.

An Evaluation of the Double Isotope Test in the Diagnosis of Pernicious Anaemia

1972 ◽  
Vol 17 (11) ◽  
pp. 359-363 ◽  
Author(s):  
R. W. Payne ◽  
R. D. Finney
Keyword(s):  
Oral Administration ◽  
Gastric Juice ◽  
Pernicious Anaemia ◽  
Diagnostic Value ◽  
The Other ◽  
Vitamin B ◽  
Human Gastric Juice ◽  
Control Subjects ◽  
Normal Human ◽  
Double Isotope

Urinary radioactivity following the simultaneous oral administration of Vitamin B12, labelled with 2 isotopes of cobalt (‘Dicopac’ test), was measured in 20 control subjects and in 20 patients suffering from pernicious anaemia: one isotope was bound to normal human gastric juice, while the other was free. The test was simple to perform and while the majority of results were of diagnostic value, some equivocal results were also obtained.

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