OBSERVATIONS ON THE MECHANISM OF THE NEUROLOGICAL COMPLICATIONS OF BEHCET'S DISEASE

Behçet’s disease is a multi-systemic vasculitis causing inflammation to blood vessels throughout the body. It is characterized most commonly by recurrent oral and genital ulcers but also susceptible to ocular, neurologic, vascular, articular, and gastrointestinal symptoms as well. Although etiology of this disease is still unclear and diagnosis is clinically based, there is a consistent association with the human leukocyte antigen complex, particularly HLA-B51.This case report used the patient’s chronic disease course along with various imaging studies to conclude the correlation of severe complications that may present later in life of these types of patients.There was positive neurological involvement indicated with an acute infarct in parts of the brain hemispheres exclusively to the temporal and parietal lobes. Central nervous system involvement was more common in this patient, which manifested with noticeable unilateral weakness along with slurred speech.Although neurologic complications within Behçet’s disease are indeed rare, it is one of the most dangerous manifestations to present in regard of an acute cerebrovascular accident (CVA). This review focused on the neurocognitive complications of chronic Behçet’s disease and how these patients should be closely monitored to help prevent the neurological complications that may present.

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Diagnosing neuro-Behçet’s disease

Romanian Journal of Neurology ◽

10.37897/rjn.2021.3.22 ◽

2021 ◽

Vol 20 (3) ◽

pp. 392-396

Author(s):

Cătălina Elena Bistriceanu ◽

◽

Florentina Anca Danciu ◽

Dan Iulian Cuciureanu ◽

◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Systemic Vasculitis ◽

Neurological Complications ◽

Cns Involvement ◽

Specific Test ◽

Behcet's Disease ◽

Neurologic Involvement ◽

Pathergy Test

Behçet’s disease is a rare systemic vasculitis characterized by uveitis, recurrent oral and genital ulcers, firstly described by the Turkish dermatologist Hulusi Behçet. The etiology is unknown, although autoimmune mechanisms are described. There is no specific test for the diagnosis of Behçet’s disease. The International Criteria for Behçet’s Disease (ICBD) proposed a new set of diagnostic criteria including oral and genital aphthosis, skin, ocular and vascular manifestations, CNS involvement and positive pathergy test. The neurologic involvement could be classified in parenchymal neuro-Behçet’s and non-parenchymal neuro-Behçet’s disease. We report a case of a woman with a very impressive personal history. Over time, she had many specific neurological complications compatible with neuro-Behçet’s disease (NBD). The other general symptoms also suggested Behçet’s disease, according to ICBD.

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P 116 Neurological complications of FK506 therapy in patients with Behçet's disease

La Revue de Médecine Interne ◽

10.1016/s0248-8663(05)82418-x ◽

1993 ◽

Vol 14 ◽

pp. 111s

Author(s):

G. Inaba

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Neurological Complications ◽

Behcet's Disease

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HLA antigens associated with Behcet's disease

Archives of Dermatology ◽

10.1001/archderm.113.12.1720 ◽

1977 ◽

Vol 113 (12) ◽

pp. 1720-1721 ◽

Cited By ~ 4

Author(s):

F. Ersoy

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Hla Antigens ◽

Behcet's Disease

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Coagulation and Fibrinolytic Activity in Behçet's Disease

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646409 ◽

1991 ◽

Vol 66 (03) ◽

pp. 292-294 ◽

Cited By ~ 57

Author(s):

K K Hampton ◽

M A Chamberlain ◽

D K Menon ◽

J A Davies

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Behçet’S Disease ◽

Fibrinolytic Activity ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Plasminogen Activator Inhibitor ◽

Behcet's Disease ◽

Tissue Plasminogen ◽

Von Willebrand

SummaryCoagulation and fibrinolytic activities were studied in 18 subjects with Behçet's disease and compared with results from 14 matched control patients suffering from sero-negative arthritis. Significantly higher plasma concentrations (median and range) were found in Behçet's patients for the following variables: fibrinogen 3.7 (1.7-6.9) vs 3.0 (2.0-5.1) g/1, p <0.05; von Willebrand factor antigen, 115 (72-344) vs 74 (60-119)%, p <0.002; plasminogen activator activity (106/ECLT2) 219 (94-329) vs 137 (78-197) units, p <0.002; tissue plasminogen activator inhibitor (t-PA-I) activity, 9.1 (5.5-19.3) vs 5.1 (1.8-12.0) IU/ml, p <0.002; and PAI-1 antigen, 13.9 (4.5-20.9) vs 6.4 (2.4-11.1) ng/ml, p <0.002. Protein C antigen was significantly lower: 97 (70-183) vs 126 (96-220)%, p <0.02. No differences were observed in antithrombin III activity or antigen, factor VIII coagulant activity, fibrinopeptides A and Bβ15-42, plasminogen, α-2-antiplasmin, functional and immunological tissue-plasminogen activator, thrombin-antithrombin complexes and D-dimer. Levels of tissue plasminogen activator inhibitor (activity and antigen) correlated with disease activity while fibrinogen and von Willebrand factor concentrations did not. Seven of the 18 subjects with Behçet's disease had suffered thrombotic events but it was not possible to distinguish these from the 11 patients without thrombosis using the assays performed. The results suggest the abnormal fibrinolytic activity in Behçet's disease is due to increased inhibition of tissue plasminogen activator. No abnormality of coagulation or fibrinolytic activity specific to Behçet's disease was detected.

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