An integrated, 3D nano-engineered exosome profiling platform (ExoProfile chip) was developed to afford ultrasensitive, multiplexed detection of a panel of surface protein markers on circulating exosomes with a minuscular volume of plasma.
A sensitive and label-free DNA detection method was developed based on cascade amplification combining exonuclease-III recycling with rolling circle amplification.
A facile fluorescent method has been developed for polynucleotide kinase detection based on copper nanoparticles and exonuclease III-assisted signal amplification.