Towards a robust water content determination of freeze-dried samples by near-infrared spectroscopy

2010 ◽  
Vol 676 (1-2) ◽  
pp. 34-40 ◽  
Author(s):  
Holger Grohganz ◽  
Delphine Gildemyn ◽  
Erik Skibsted ◽  
James M. Flink ◽  
Jukka Rantanen
Keyword(s):  
Infrared Spectroscopy ◽  
Water Content ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Content Determination ◽  
Freeze Dried

scholarly journals Elaboration of near infrared spectroscopy model for determination of water content in freeze-dried immunological veterinary medicinal products

2016 ◽  
Author(s):  
Krzysztof Bulenger ◽  
Dorota Marta Krasucka ◽  
Bogumił Biernacki ◽  
Jakub Szumiło ◽  
Beata Cuvelier
Keyword(s):  
Infrared Spectroscopy ◽  
Water Content ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Residual Water ◽  
Medicinal Products ◽  
Karl Fischer Titration ◽  
Karl Fischer ◽  
Veterinary Medicinal Products

Residual water is a critical parameter in assessing the quality of immunological veterinary medicinal products (IVMPs). In majority of the laboratories the Karl Fischer titration (KFT) is used for the determination of water content in IVMPs. However, the transfer of IVMP into titration cell without affecting the baseline drift and repeatability seems to be the main problem when using this method. In turn, Near Infrared Spectroscopy (NIRS) allows measurement of closed vials, therefore eliminating the impact of atmospheric conditions on the sample. The aim of the study was to create a calibration model based on the reference method (Karl Fischer titration) and its optimization. Five different IVMPs designated for two animal species (dogs and rabbits) were used. The model was constructed on the basis of 49 samples tested, each in triplicate (n=147). The spectra were divided in two sets: calibration and validation. Proper selection of samples and their processing allowed to obtain a model of high quality (Q-value>0.6).

Determination of Water Content in Bovine Lenses Using Near-Infrared Spectroscopy

1997 ◽  
Vol 29 (6) ◽  
pp. 429-435 ◽  
Author(s):  
Jeffrey M. Zink ◽  
Jack L. Koenig ◽  
Theodore R. Williams
Keyword(s):  
Infrared Spectroscopy ◽  
Water Content ◽  
Near Infrared Spectroscopy ◽  
Near Infrared

Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool

Talanta ◽  
2015 ◽  
Vol 144 ◽  
pp. 1352-1359 ◽  
Author(s):  
Pierre-François Chavez ◽  
Pierre-Yves Sacré ◽  
Charlotte De Bleye ◽  
Lauranne Netchacovitch ◽  
Jérôme Mantanus ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Pharmaceutical Tablets ◽  
Content Determination ◽  
Technology Tool ◽  
Analytical Technology ◽  
Active Content
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